ArticleJournal of clinical neurology (Seoul, Korea)2025
Multiple Sclerosis After the Age of 50 Years: A Comparative Analysis of Late Onset and Adult Onset.
Article in Journal of clinical neurology (Seoul, Korea), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Structural MRI signature of late- versus adult-onset multiple sclerosis: a multiparametric study.Journal of neurology · 2026Article
- Astrocyte Heterogeneity in Multiple Sclerosis From Reactive Glia to Therapeutic Targets.Journal of clinical neurology (Seoul, Korea) · 2026Article
- Clinical, functional and cognitive features of late-onset multiple sclerosis.Journal of neurology · 2025Article
- Longitudinal changes in sleep quality, and their predictors in patients with multiple sclerosis.Scientific reports · 2025Article
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Authors and funding
7 authors.
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No grant is acknowledged in the PubMed record.
Abstract
background and purposeThe incidence of multiple sclerosis (MS) among older patients is increasing. Some of these patients develop the disease after the age of 50 years, a condition known as late-onset MS (LOMS). This study aimed to characterize MS in older patients (50-75 years-old) by comparing LOMS with adult-onset MS (AOMS).
methodsWe retrospectively analyzed data from 230 patients aged 50-75 years who attended a Portuguese tertiary referral center.
resultsThis study included 189 AOMS patients aged 58 [54-63] years (median [interquartile range]) and 41 LOMS patients aged 67 [61-70] years. Females predominated in both the LOMS (70.7%) and AOMS (75.1%) groups. Primary progressive MS was more common in LOMS than AOMS patients (19.5% vs. 8.0%,
conclusionsThe LOMS patients presented with higher EDSS scores at the diagnosis, reaching a level of disability not significantly different from AOMS patients of the same age group despite a shorter disease course.
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