SynthesisSystematic reviews2025
Systematic review and meta-analysis of Jueyin disease theory in the treatment of gangrene with traditional Chinese medicine formulations.
Synthesis in Systematic reviews, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Cellulose-Based Hydrogels for Chronic Wound Healing: Bridging Biomaterial Design and Clinical Unmet Needs.Gels (Basel, Switzerland) · 2026Review
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
objectiveThis review aims to systematically evaluate the application of Jueyin disease theory in the diagnosis and treatment of gangrene within the framework of traditional Chinese medicine (TCM). Through systematic review and meta-analysis, the efficacy of commonly used TCM formulations, including Wumei pill, Pulsatilla decoction, and Dang-Gui-Si-Ni decoction, is explored.
methodsA systematic search of PubMed, Web of Science, and CNKI was conducted, integrating meta-analysis and systematic review. Clinical trials and case reports based on Jueyin disease theory for gangrene treatment were included. Data extraction, quality assessment, and statistical analyses were performed.
resultsA total of nine studies met the inclusion criteria. The meta-analysis indicated that TCM formulations significantly improved clinical outcomes, particularly in enhancing the ankle-brachial index (ABI) and maximum walking distance, with mean differences of 0.17 (95% CI, 0.11, 0.24; p < 0.01) and 293.22 (95% CI, 174.85, 411.60; p < 0.01), respectively. Sensitivity analysis and tests for publication bias confirmed the robustness and consistency of the findings. Sensitivity analysis and publication bias assessment confirmed the robustness and reliability of the results.
conclusionJueyin disease theory and its related formulas (Wumei pill, Pulsatilla decoction, and Dang-Gui-Si-Ni decoction) demonstrate significant clinical value in traditional Chinese medicine (TCM) treatment of gangrene, effectively improving clinical symptoms and blood circulation. The findings provide scientific evidence for the modern application of Jueyin disease theory in TCM while acknowledging limitations such as small sample sizes and study heterogeneity, offering valuable insights for future research and clinical practice.
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Registered trials
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