Case report: late adverse reactions in an epilepsy patient on combination therapy with valproate and lamotrigine.

Hui Sang, Liqiao Zhao, Yanhua Zhang, Xiaolong Wang, Xiaodong Zhang

Abstract read

In one paragraph

Article in Acta epileptologica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Hui SangDepartment of Neurology, Taiyuan City Central Hospital, The Ninth Clinical Medical College of Shanxi Medical University, Taiyuan, 030001, China.

Liqiao ZhaoDepartment of Neurology, Taiyuan City Central Hospital, The Ninth Clinical Medical College of Shanxi Medical University, Taiyuan, 030001, China.

Yanhua ZhangDepartment of Neurology, Taiyuan City Central Hospital, The Ninth Clinical Medical College of Shanxi Medical University, Taiyuan, 030001, China.

Xiaolong WangDepartment of Neurology, Taiyuan City Central Hospital, The Ninth Clinical Medical College of Shanxi Medical University, Taiyuan, 030001, China.

Xiaodong ZhangDepartment of Neurology, Taiyuan City Central Hospital, The Ninth Clinical Medical College of Shanxi Medical University, Taiyuan, 030001, China. Dr_XiaodongZhang@outlook.com.

Funding

Basic Research Program of Shanxi Provincial Department of Science and Technology 202203021221299

6 · The paper itself

Abstract

backgroundLate adverse reactions associated with the combined therapy of valproate and lamotrigine are infrequently documented within the Chinese population. CASE PRESENTATION: This case report describes a 54-year-old female patient who developed adverse reactions following long-term therapy with valproate and lamotrigine, with symptoms emerging five months after the final adjustment of her antiseizure regimen. The patient presented with symptoms of dizziness, ataxia, nystagmus, and postural tremors. Following blood drug concentration monitoring and subsequent minor dosage adjustments to the antiseizure regimen without medication withdrawal, the patient's symptoms were successfully resolved.

conclusionsThis article underscores the importance of vigilance among clinicians regarding the potential for late adverse reactions and advocates for the proactive monitoring of blood drug concentrations.

Indexed as

Adverse reactionsLamotrigineValproate

Identifiers

PMID40307904

DOI10.1186/s42494-025-00217-3

PMCPMC12042444

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.