Evidence map›Paper›PMID 40307788›Full record

ArticleBMC oral health2025

Study on the potential links between clinical features of oral lichenoid mucositis and systemic diseases.

Peilin Wang, Peipei Yan, Yihang Zhang, Yanjie Li, Fei Du, Miao Zhang, Rong Wang, Yingbing Yan, Hongkai Zhang, Ruiyang Chen and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC oral health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Peilin Wang *Department of Oral Mucosal Diseases, Tianjin Stomatological Hospital, School of Medicine, Nankai University, Tianjin, 300041, China.
Peipei Yan *Department of Oral Mucosal Diseases, Tianjin Stomatological Hospital, School of Medicine, Nankai University, Tianjin, 300041, China.
Yihang ZhangDepartment of Oral Mucosal Diseases, Tianjin Stomatological Hospital, School of Medicine, Nankai University, Tianjin, 300041, China.
Yanjie LiDepartment of Oral Mucosal Diseases, Tianjin Stomatological Hospital, School of Medicine, Nankai University, Tianjin, 300041, China.
Fei DuDepartment of Oral Mucosal Diseases, Tianjin Stomatological Hospital, School of Medicine, Nankai University, Tianjin, 300041, China.
Miao ZhangDepartment of Oral Mucosal Diseases, Tianjin Stomatological Hospital, School of Medicine, Nankai University, Tianjin, 300041, China.
Rong WangDepartment of Oral Mucosal Diseases, Tianjin Stomatological Hospital, School of Medicine, Nankai University, Tianjin, 300041, China.
Yingbing YanDepartment of Oromaxillofacial-Head and Neck Surgery, Tianjin Stomatological Hospital, School of Medicine, Nankai University, Tianjin, 300041, China.
Hongkai ZhangState Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin, 300071, China.
Ruiyang ChenDepartment of Oral Mucosal Diseases, Tianjin Stomatological Hospital, School of Medicine, Nankai University, Tianjin, 300041, China.
Chenlu LiuDepartment of Oral Mucosal Diseases, Tianjin Stomatological Hospital, School of Medicine, Nankai University, Tianjin, 300041, China. liuchenlu@nankai.edu.cn.

Funding

the Key Laboratory of Oral Function Reconstruction Fund of Tianjin No. 2023KLQN07the Open Fund of the State Key Laboratory of Medicinal Chemical Biology No. 2018056the Tianjin Stomatological Hospital Ph.D. and Master's Key Project No. 2019BSZD05
6 · The paper itself

Abstract

objectiveThis study aimed to analyze the clinical characteristics of oral lichenoid disease and investigate its potential association with systemic diseases.

methodsThis study was a retrospective cross-sectional analysis. The study comprised 116 patients who had been diagnosed with oral lichenoid disease, including 70 with oral lichen planus and 46 with lichenoid lesions. The study meticulously documented the distribution and types of lesions in oral lichenoid disease patients.

resultsThe average age was 46 years, with females representing 69.8% and males 30.2%. The prevalence of major systemic diseases among these patients was notable: thyroid disorders were observed in 64.7%, dyslipidemia in 44.0%, hyperuricemia in 36.2%, hypertension in 28.5%, and diabetes in 21.6%. Significant associations were found between specific lesion sites and systemic diseases. Network-like lesions in the gingival-buccal groove were highly correlated with thyroid disorders (P < 0.000). Lichenoid lesions on the lips were significantly associated with dyslipidemia (P < 0.002). Furthermore, lesions on both the dorsal (P < 0.000) and ventral (P < 0.038) surfaces of the tongue, particularly patchy lesions on the dorsal surface, showed a strong association with hyperuricemia.

conclusionThese findings indicated a significant correlation between the clinical manifestations of oral lichenoid disease and systemic conditions such as thyroid disorders, dyslipidemia, and hyperuricemia.

Indexed as

Lichen Planus, OralStomatitisAdultAgedCross-Sectional StudiesDyslipidemiasFemaleHumansHypertensionHyperuricemiaMaleMiddle AgedRetrospective StudiesThyroid DiseasesYoung AdultDiabetesDyslipidemiaHypertensionHyperuricemiaLichenoid lesionsOral lichenoid diseaseOral lichen planusThyroid disorders

Identifiers

PMID40307788
PMCPMC12044897

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.