Evidence map›Paper›PMID 40307640›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2025

Toxicity Testing Using Organoids Made from Human-Induced Pluripotent Stem Cells Engineered to Report Oxidative Stress.

Mona Elhendawi, Melanie L Lawrence, Jamie A Davies

Abstract read
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In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Mona ElhendawiDeanery of Biomedical Sciences and Centre for Engineering Biology, University of Edinburgh, Edinburgh, UK.
Melanie L LawrenceDeanery of Biomedical Sciences and Centre for Engineering Biology, University of Edinburgh, Edinburgh, UK.
Jamie A DaviesDeanery of Biomedical Sciences and Centre for Engineering Biology, University of Edinburgh, Edinburgh, UK. Jamie.Davies@ed.ac.uk.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This article describes the engineering of human induced pluripotent stem cells to report a cellular response to oxidative stress, which is a common (but not universal) result of cells being exposed to a toxicant. It then describes the use of these cells to generate renal organoids that will report oxidative stress, and the use of these organoids to screen a panel of compounds for nephrotoxicity. This application is intended as an illustration; in principle, other organoids could be made from these cells, and other cell lines could be made to report different common markers of cellular stress (for example, the release of pro-inflammatory signals).

Indexed as

Induced Pluripotent Stem CellsOrganoidsOxidative StressToxicity TestsCell LineHumansKidneyDrug screeningHuman-induced pluripotent stem cells (hiPSC)Kidney organoidNephrotoxicityOrganoidsOxidative stressRenal organoid

Identifiers

PMID40307640

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.