Observational studyEuropean journal of clinical nutrition2025
Maternal first trimester SIMPLE nutritional score, early markers of placental function and pregnancy outcome: a prospective multicenter Italian study (SIMPLE study).
Observational study in European journal of clinical nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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Who cites it
1 citing paper in PubMed.
- Maternal Pregestational Body Mass Index and Delivery Outcomes: A Retrospective Study in a Tertiary High-Income Setting.Journal of nutrition and metabolism · 2026Review
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Authors and funding
16 authors.
Funding
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Abstract
objectiveTo evaluate associations between the first trimester SIMPLE nutritional score, early placental markers, and pregnancy outcome.
methodsThis is a longitudinal prospective multicenter observational cohort study recruiting healthy women with no comorbidities and singleton viable pregnancies undergoing first trimester prenatal screening. The SIMPLE nutritional score, biochemical (pregnancy-associated plasma protein A (PAPP-a), free ß-human chorionic gonadotropin (β-HCG)) and ultrasound (placental volume, uterine artery Doppler velocimetry) markers of placental function were collected at enrollment. Birth outcomes were collected at delivery.
main outcome measuresMultivariate generalized linear and logistic regression models were performed to investigate associations between SIMPLE score subgroups (<6 versus ≥6) and items, placental markers, and pregnancy outcomes.
resultsOut of 2363 women enrolled, 325 were classified at high nutritional risk based on a first trimester SIMPLE score lower than 6. Multi-adjusted models showed that the SIMPLE score subgroup was significantly associated with first trimester PAPP-a concentrations (SIMPLE score ≥6 versus <6: β = 0.047 (95% CI 0.004;0.089), p < 0.05), as well as with the emergency cesarean section rates (SIMPLE score ≥6 versus <6: aOR = 0.73 (95% CI -1.38;-0.07), p < 0.05). The single item related to the first trimester hemoglobin concentrations higher than 110 g/L was significantly associated with early placental markers, birth (β = -116.2 (95% CI -213.6;18.7), p < 0.05) and placental weights (β = -28.2 (95% CI -50.4;6.0), p < 0.05) in multi-adjusted models.
conclusionsThe observed associations support the introduction of the SIMPLE score in clinical practice as a useful tool for predicting early placental development and pregnancy outcome.
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