Evidence map›Paper›PMID 40307575›Full record

ArticleCommunications chemistry2025

Structural convergence and membrane interactions of Aβ

Maurine K Kengwerere, June M Kenyaga, Peng Xiao, Shubha S Gunaga, Faith J Scott, Xyomara Wutoh-Hughes, James Wang, Brian Lum, Yan Sun, Frederic Mentink-Vigier and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Communications chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Amyloid Beta Oligomers as Early Triggers of Neuronal Cytoskeleton Dysfunction in Alzheimer's Disease.Pathophysiology : the official journal of the International Society for Pathophysiology · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Maurine K KengwerereDepartment of Chemistry, Binghamton University, State University of New York, Binghamton, NY, USA.
June M KenyagaDepartment of Chemistry, Binghamton University, State University of New York, Binghamton, NY, USA.ORCID http://orcid.org/0000-0001-8937-0822
Peng XiaoDepartment of Chemistry, Michigan State University, East Lansing, MI, USA.ORCID http://orcid.org/0000-0002-6430-0278
Shubha S GunagaNational High Magnetic Field Laboratory, Florida State University, Tallahassee, FL, USA.
Faith J ScottNational High Magnetic Field Laboratory, Florida State University, Tallahassee, FL, USA.
Xyomara Wutoh-HughesDepartment of Chemistry, Binghamton University, State University of New York, Binghamton, NY, USA.
James WangDepartment of Chemistry, Binghamton University, State University of New York, Binghamton, NY, USA.
Brian LumDepartment of Chemistry, Binghamton University, State University of New York, Binghamton, NY, USA.
Yan SunSmall Scale System Integration and Packaging (S3IP), Binghamton University, Binghamton, NY, USA.
Frederic Mentink-VigierNational High Magnetic Field Laboratory, Florida State University, Tallahassee, FL, USA.ORCID http://orcid.org/0000-0002-3570-9787
Tuo WangDepartment of Chemistry, Michigan State University, East Lansing, MI, USA.ORCID http://orcid.org/0000-0002-1801-924X
Wei QiangDepartment of Chemistry, Binghamton University, State University of New York, Binghamton, NY, USA. wqiang@binghamton.edu.ORCID http://orcid.org/0000-0002-0044-810X

Funding

National Resource for Advanced NMR TechnologyRM1GM148766 · NIGMS · FLORIDA STATE UNIVERSITY · PI William W Brey, Joanna R Long · 2023 to 2026
$4.9M
Molecular Structural Basis of Non-specific Neuronal Membrane Disruption Induced by Early-Stage Beta-Amyloid Peptide AggregationR01GM125853 · NIGMS · STATE UNIVERSITY OF NY,BINGHAMTON · PI Wei Qiang · 2018 to 2026
$2.5M
NIGMS NIH HHS R01 GM125853NIGMS NIH HHS RM1 GM148766U.S. Department of Health & Human Services | National Institutes of Health (NIH) GM125853
6 · The paper itself

Abstract

Non-specific disruption of cellular membranes induced by amyloidogenic aggregation of β-amyloid (Aβ) peptides remains a viable cytotoxicity mechanism in Alzheimer's disease (AD). Obtaining structural information about the intermediate states of Aβ-membrane systems and their molecular interactions is challenging due to their heterogeneity and low abundance. Here, we systematically study the molecular interactions of membrane-associated Aβ

Identifiers

PMID40307575
PMCPMC12043865

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.