ReviewExperimental & molecular medicine2025
Lateral hypothalamus and eating: cell types, molecular identity, anatomy, temporal dynamics and functional roles.
Review in Experimental & molecular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed.
- Altered hypothalamic functional connectivity in adolescents with severe obesity.International journal of obesity (2005) · 2026Observational
- The hindbrain-hypothalamic noradrenergic pathway controls homeostatic food intake but not cue-induced appetitive behaviors.Journal of neuroendocrinology · 2026Article
- Balancing acts: lateral hypothalamic circuits coordinating feeding, anxiety, and social interactions.Reviews in endocrine & metabolic disorders · 2026Review
- Novelty exploration-activated ensemble in the lateral hypothalamus confers analgesic and anxiolytic effects.Nature communications · 2026Article
- Lateral hypothalamus directs stress-induced modulation of acute and psoriatic itch.Cell reports · 2026Article
- Obesogenic effects of warm temperature involve feeding adaptation by preoptic area leptin receptor neurons.Communications biology · 2026Article
- Altered Hypothalamic functional connectivity in adolescents with severe obesity.Research square · 2026Article
- Sex-associated circadian signaling signatures in the lateral hypothalamus.Frontiers in sleep · 2026Article
- Histological evaluation of thermosensory receptors and cutaneous neurovascular in the tail skin of BALB/c mice.Open veterinary journal · 2025Article
- Hypothalamic Orexin Projections to the Hippocampal CA1 Region Alleviate Cognitive and Synaptic Plasticity Impairments Induced by Blue Light Exposure.CNS neuroscience & therapeutics · 2025Article
- Hijacked Brain in Modern Obesity: Cue, Habit, Addiction, Emotion, and Restraint as Targets for Personalized Digital Therapy and Electroceuticals.Journal of obesity & metabolic syndrome · 2025Review
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
The lateral hypothalamus (LH) is a central hub orchestrating eating behavior through its complex cellular, anatomical and temporal organization. The LH is characterized by high heterogeneity and functional complexity, with many aspects still unexplored. Here we synthesize recent advances in understanding the role of the LH in eating regulation across multiple dimensions. At the cellular level, the LH contains diverse neuronal populations that contribute to distinct roles in behavior. Anatomically, we divided the LH into four regions-anteromedial, anterolateral, posteromedial and posterolateral-each with unique cellular compositions, circuit organizations and projection patterns. By integrating the temporal dynamics of each LH cell type during eating behavior, we identified how various LH cell types are involved in regulating the appetitive and consummatory phases of eating behavior. The LH also plays vital roles in associative learning and different types of eating behavior, including homeostatic, pleasure-induced and stress-induced eating. These insights into LH organization and function provide promising directions for therapeutic interventions in eating disorders and obesity, including drugs, deep brain stimulation and gene therapy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.