Evidence map›Paper›PMID 40307551›Full record

ArticleNature2025

Diet outperforms microbial transplant to drive microbiome recovery in mice.

M S Kennedy, A Freiburger, M Cooper, K Beilsmith, M L St George, M Kalski, C Cham, A Guzzetta, S C Ng, F K Chan and 5 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. Review
  12. Review
  13. Review
  14. Polysaccharides from the Cherry Peel ofFoods (Basel, Switzerland) · 2026
    Article
  15. Article
  16. Review
  17. Review
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

M S KennedyMedical Scientist Training Program, Pritzker School of Medicine, The University of Chicago, Chicago, IL, USA.ORCID 0000-0001-6472-2182
A FreiburgerDivision of Data Science and Learning, Argonne National Laboratory, Lemont, IL, USA.ORCID 0000-0002-7288-535X
M CooperDepartment of Medicine, The University of Chicago, Chicago, IL, USA.
K BeilsmithDivision of Data Science and Learning, Argonne National Laboratory, Lemont, IL, USA.ORCID 0000-0003-2778-299X
M L St GeorgeDepartment of Medicine, The University of Chicago, Chicago, IL, USA.ORCID 0000-0003-4262-5941
M KalskiDepartment of Medicine, The University of Chicago, Chicago, IL, USA.
C ChamDepartment of Medicine, The University of Chicago, Chicago, IL, USA.ORCID 0000-0001-7135-949X
A GuzzettaDepartment of Pathology, The University of Chicago, Chicago, IL, USA.ORCID 0000-0002-8809-7438
S C NgMicrobiota I-Center (MagIC), Department of Medicine and Therapeutics, LKS Institute of Health Science, Institute of Digestive Disease, Center for Gut Microbiota Research, The Chinese University of Hong Kong, Hong Kong SAR, China.ORCID 0000-0002-6850-4454
F K ChanMicrobiota I-Center (MagIC), Department of Medicine and Therapeutics, LKS Institute of Health Science, Institute of Digestive Disease, Center for Gut Microbiota Research, The Chinese University of Hong Kong, Hong Kong SAR, China.
O DeLeonDepartment of Medicine, The University of Chicago, Chicago, IL, USA.
D RubinInflammatory Bowel Disease Center, University of Chicago Medicine, Chicago, IL, USA.ORCID 0000-0001-5647-1723
C S HenryDivision of Data Science and Learning, Argonne National Laboratory, Lemont, IL, USA.
J BergelsonDepartment of Biology, Center for Genomics and Systems Biology, New York University, New York, NY, USA.
E B ChangDepartment of Medicine, The University of Chicago, Chicago, IL, USA. echang@bsd.uchicago.edu.ORCID 0000-0001-5972-8248

Funding

MEDICAL SCIENTIST TRAININGT32GM007281 · NIGMS · UNIVERSITY OF CHICAGO · PI CLARK, MARCUS RAMSAY · 1985 to 2022
$32.1M
Research Training in Digestive Health, Diseases, and NutritionT32DK007074 · NIDDK · UNIVERSITY OF CHICAGO · PI EUGENE B CHANG · 1986 to 2026
$11.3M
Host and microbial basis of human ulcerative colitis and pouchitis: Identification, role, mechanisms, and resource development of host susceptibility and pathobiont factorsRC2DK122394 · NIDDK · UNIVERSITY OF CHICAGO · PI CHANG, EUGENE B · 2019 to 2023
$10.2M
NIDDK NIH HHS RC2 DK122394NIDDK NIH HHS T32 DK007074NIGMS NIH HHS T32 GM007281
6 · The paper itself

Abstract

A high-fat, low-fibre Western-style diet (WD) induces microbiome dysbiosis characterized by reduced taxonomic diversity and metabolic breadth

Indexed as

Diet, WesternDysbiosisFecal Microbiota TransplantationGastrointestinal MicrobiomeAnimalsAnti-Bacterial AgentsDiet, High-FatFecesFemaleMaleMiceMice, Inbred C57BLSalmonella InfectionsSalmonella typhimuriumAnti-Bacterial Agents

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.