Evidence map›Paper›PMID 40307550›Full record

ArticleNature2025

Serotonin and neurotensin inputs in the vCA1 dictate opposing social valence.

Julia M Zorab, Huanhuan Li, Richa Awasthi, Anna Schinasi, Yoonjeong Cho, Thomas O'Loughlin, Xiaoting Wu

Abstract read
In one paragraph

Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Distinct neural dynamics in the ventral hippocampus and medial prefrontal cortex during social information processing.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  8. Hippocampal CA2 to CA1: A metaplastic switch for memory encoding.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  9. Article
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Julia M ZorabDepartment of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Huanhuan LiDepartment of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Richa AwasthiDepartment of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Anna SchinasiDepartment of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Yoonjeong ChoDepartment of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Thomas O'LoughlinDepartment of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0002-4783-2352
Xiaoting WuDepartment of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA. xiaoting.wu@mssm.edu.ORCID 0000-0003-0036-6902

Funding

Neural Mechanisms of Social Information ProcessingR01MH136228 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Xiaoting Wu · 2024 to 2026
$2.5M
The role of the septum in social memoryR00MH122697 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI WU, XIAOTING · 2022 to 2024
$747k
The role of the septum in social memoryK99MH122697 · NIMH · STANFORD UNIVERSITY · PI WU, XIAOTING · 2020 to 2021
$218k
NIMH NIH HHS K99 MH122697NIMH NIH HHS R00 MH122697NIMH NIH HHS R01 MH136228
6 · The paper itself

Abstract

The ability to evaluate valence of a social agent based on social experience is essential for an animal's survival in its social group

Indexed as

NeurotensinSerotoninSocial BehaviorAnimalsCA1 Region, HippocampalDorsal Raphe NucleusFemaleMaleMiceMice, Inbred C57BLMidline Thalamic NucleiOptogeneticsPyramidal CellsReceptor, Serotonin, 5-HT1BReceptors, NeurotensinRewardNeurotensinneurotensin type 1 receptorReceptor, Serotonin, 5-HT1BReceptors, NeurotensinSerotonin

Identifiers

PMID40307550
PMCPMC12137126

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.