ArticleNature2025
Comparative connectomics of Drosophila descending and ascending neurons.
Abstract readComparative Study
In one paragraph
Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed.
- Article
- Synaptic Organization of the Primate Retina: Toward a Human Foveal Connectome.Annual review of vision science · 2026Review
- Article
- Article
- Uncovering Sex Differences in thebioRxiv : the preprint server for biology · 2026Article
- Article
- Connectome simulations identify a central pattern generator circuit for fly walking.bioRxiv : the preprint server for biology · 2026Article
- Long-range axon branching: contributions to brain network plasticity and repair.Nature reviews. Neuroscience · 2026Review
- Segmentally repeated ventral nerve cord circuits drive different leg rubbing behaviors iniScience · 2026Article
- Organization and evolution of sex-biased gene expression inbioRxiv : the preprint server for biology · 2026Article
- Neural bottlenecks: axon count, distribution, and conduction in the Manduca sexta neck connective.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2026Article
- Cis-regulatory fragments from the dissatisfaction gene identify novel mating behavior neurons in female Drosophila.G3 (Bethesda, Md.) · 2026Article
- Drosophila DNp03 descending neurons serve as a hub within a flight saccade network.Current biology : CB · 2026Article
- Sleep regulation inFrontiers in neuroscience · 2026Review
- Using comparative connectomics to understand variability and evolution in neural circuits.Nature methods · 2025Article
- Neural evolution of complex motor behaviors: insights from Drosophila courtship song.Current opinion in neurobiology · 2025Review
- Article
- Sexual dimorphism in the complete connectome of thebioRxiv : the preprint server for biology · 2025Article
- A neural circuit for context-dependent multimodal signaling in Drosophila.Nature communications · 2025Article
- Sexually-dimorphic neurons in theResearch square · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
37 authors.
Tomke Stürner *Neurobiology Division, MRC Laboratory of Molecular Biology, Cambridge, UK.ORCID 0000-0003-4054-0784
Paul Brooks *Drosophila Connectomics Group, Department of Zoology, University of Cambridge, Cambridge, UK.ORCID 0000-0001-5998-6378
Laia Serratosa CapdevilaDrosophila Connectomics Group, Department of Zoology, University of Cambridge, Cambridge, UK.
Billy J MorrisDrosophila Connectomics Group, Department of Zoology, University of Cambridge, Cambridge, UK.
Alexandre JavierDrosophila Connectomics Group, Department of Zoology, University of Cambridge, Cambridge, UK.
Siqi FangDrosophila Connectomics Group, Department of Zoology, University of Cambridge, Cambridge, UK.
Marina GkantiaDrosophila Connectomics Group, Department of Zoology, University of Cambridge, Cambridge, UK.
Sebastian CacheroNeurobiology Division, MRC Laboratory of Molecular Biology, Cambridge, UK.ORCID 0000-0002-6828-1211
Isabella R BeckettNeurobiology Division, MRC Laboratory of Molecular Biology, Cambridge, UK.
Elizabeth C MarinDrosophila Connectomics Group, Department of Zoology, University of Cambridge, Cambridge, UK.ORCID 0000-0001-6333-0072
Philipp SchlegelNeurobiology Division, MRC Laboratory of Molecular Biology, Cambridge, UK.ORCID 0000-0002-5633-1314
Andrew S ChampionDrosophila Connectomics Group, Department of Zoology, University of Cambridge, Cambridge, UK.
Ilina MoitraDrosophila Connectomics Group, Department of Zoology, University of Cambridge, Cambridge, UK.
Alana RichardsDrosophila Connectomics Group, Department of Zoology, University of Cambridge, Cambridge, UK.
Finja KlemmGenetics Department, Leipzig University, Leipzig, Germany.ORCID 0009-0005-3800-3244
Leonie KugelGenetics Department, Leipzig University, Leipzig, Germany.ORCID 0009-0006-9347-5751
Shigehiro NamikiResearch Center for Advanced Science and Technology, University of Tokyo, Tokyo, Japan.ORCID 0000-0003-1559-799X
Han S J CheongJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA.ORCID 0000-0001-5233-3438
Julie KovalyakJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA.
Emily TenshawJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA.
Ruchi ParekhJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA.
Jasper S PhelpsDepartment of Neurobiology, Harvard Medical School, Boston, MA, USA.ORCID 0000-0001-8033-258X
Brandon MarkDepartment of Neurobiology and Biophysics, University of Washington, Seattle, WA, USA.
Sven DorkenwaldPrinceton Neuroscience Institute, Princeton University, Princeton, NJ, USA.
Alexander S BatesNeurobiology Division, MRC Laboratory of Molecular Biology, Cambridge, UK.ORCID 0000-0002-1195-0445
Arie MatsliahPrinceton Neuroscience Institute, Princeton University, Princeton, NJ, USA.
Szi-Chieh YuPrinceton Neuroscience Institute, Princeton University, Princeton, NJ, USA.ORCID 0009-0001-9684-0156
Claire E McKellarPrinceton Neuroscience Institute, Princeton University, Princeton, NJ, USA.
Amy SterlingPrinceton Neuroscience Institute, Princeton University, Princeton, NJ, USA.
H Sebastian SeungPrinceton Neuroscience Institute, Princeton University, Princeton, NJ, USA.ORCID 0000-0002-8591-6733
Mala MurthyPrinceton Neuroscience Institute, Princeton University, Princeton, NJ, USA.ORCID 0000-0003-3063-3389
John C TuthillDepartment of Neurobiology and Biophysics, University of Washington, Seattle, WA, USA.ORCID 0000-0002-5689-5806
Wei-Chung Allen LeeDepartment of Neurobiology, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-4618-295X
Gwyneth M CardJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA.
Marta CostaDrosophila Connectomics Group, Department of Zoology, University of Cambridge, Cambridge, UK.ORCID 0000-0001-5948-3092
Gregory S X E JefferisNeurobiology Division, MRC Laboratory of Molecular Biology, Cambridge, UK. jefferis@mrc-lmb.cam.ac.uk.ORCID 0000-0002-0587-9355
Katharina EichlerDrosophila Connectomics Group, Department of Zoology, University of Cambridge, Cambridge, UK. katharina.eichler@uni-leipzig.de.ORCID 0000-0002-7833-8621
Funding
Dissemination of FlyWire, A Whole-Brain Connectomics ResourceU24NS126935 · NINDS · PRINCETON UNIVERSITY · PI Mala Murthy · 2022 to 2026
$5.6MUncovering the Neural Mechanisms that Flexibly Link Sensory Processing to BehaviorR35NS111580 · NINDS · PRINCETON UNIVERSITY · PI Mala Murthy · 2019 to 2026
$5.0MTools to broaden access to high-throughput functional connectomicsRF1MH117808 · NIMH · HARVARD MEDICAL SCHOOL · PI LEE, WEI-CHUNG ALLEN, MACRINA, THOMAS · 2019 to 2019
$4.3MCrowdsourcing the Fly ConnectomeRF1MH117815 · NIMH · PRINCETON UNIVERSITY · PI MURTHY, MALA, SEUNG, HYUNJUNE SEBASTIAN · 2018 to 2018
$3.3MAccelerating connectomic proofreading for larger brains and multiple individualsRF1MH129268 · NIMH · PRINCETON UNIVERSITY · PI MURTHY, MALA · 2022 to 2022
$2.1MAutomating whole brain connectomics: development, validation, and application of an open toolkitRF1MH120679 · NIMH · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI BOCK, DAVI · 2019 to 2019
$1.9MNIMH NIH HHS RF1 MH117808NIMH NIH HHS RF1 MH117815NIMH NIH HHS RF1 MH120679NIMH NIH HHS RF1 MH129268NINDS NIH HHS R35 NS111580NINDS NIH HHS U24 NS126935Wellcome Trust
Abstract
In most complex nervous systems there is a clear anatomical separation between the nerve cord, which contains most of the final motor outputs necessary for behaviour, and the brain. In insects, the neck connective is both a physical and an information bottleneck connecting the brain and the ventral nerve cord (an analogue of the spinal cord) and comprises diverse populations of descending neurons (DNs), ascending neurons (ANs) and sensory ascending neurons, which are crucial for sensorimotor signalling and control. Here, by integrating three separate electron microscopy (EM) datasets
Indexed as
ConnectomeDrosophila melanogasterNeuronsAnimalsBrainCourtshipFemaleMaleNeckSex CharacteristicsSexual Behavior, Animal
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.