ArticleNature2025
Global evolution of inflammatory bowel disease across epidemiologic stages.
Registry-linked trialAbstract readHistorical Article
In one paragraph
Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07155148 (Argentine Registry of Crohn's Disease and Ulcerative Colitis), which is not on this map. Cited by 260 papers, 8 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
260citing papers in PubMed, 8 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Argentine Registry of Crohn's Disease and Ulcerative Colitis
Who cites it
260 citing papers in PubMed, 8 syntheses or guidelines pooled it.
- Comparing access routes and anastomotic techniques for right-sided colonic resections: meta-analysis of randomized clinical trials.Surgical endoscopy · 2026Pooled it
- Meta-Analysis: Prevalence of Eating Disorders in Inflammatory Bowel Disease.Alimentary pharmacology & therapeutics · 2026Pooled it
- Adherence to biologics in patients with inflammatory bowel disease: a systematic review and meta-analysis.International journal of clinical pharmacy · 2026Pooled it
- Gut microbiota alterations associated with anxiety and depression in inflammatory bowel disease: a systematic review of prospective cohorts and randomized trials.Frontiers in microbiology · 2026Pooled it
- Research hotspots, context, and future directions of ulcerative colitis comorbid with depression from 2006 to 2025: a bibliometric and visualization analysis.Frontiers in medicine · 2026Pooled it
- Comparative efficacy of dietary interventions and enteral nutrition in adults with ulcerative colitis: a network meta-analysis.Frontiers in nutrition · 2026Pooled it
- REGIONAL AND MULTIFACTORIAL PATTERNS OF INFLAMMATORY BOWEL DISEASE IN BRAZIL: A SYSTEMATIC ANALYSIS OF HOT SPOTS IN WESTERN SÃO PAULO AND PARANÁ.Arquivos de gastroenterologia · 2026Pooled it
- Inflammatory bowel disease and the risk of all caused or specific fracture: a meta-epidemiologic study.Frontiers in endocrinology · 2026Pooled it
- Construction and clinical validation of a Team STEPPS-based discharge planning program for patients with inflammatory bowel disease.Frontiers in medicine · 2026Trial
- Soil-derived microbiota induces T regulatory cells and protect against mouse colitis, metabolic disease, and sepsis.Gut microbes · 2026Article
- ROS-responsive small-molecule self-assembled nanocarrier-integrated hydrogels for ulcerative colitis treatment.Materials today. Bio · 2026Article
- Crosstalk between circRNAs and the classic signaling pathways in IBD.RNA biology · 2026Review
- Current perspectives and future horizons in predicting response to nutrition therapy in children with Crohn's disease - a narrative review.Pediatric research · 2026Review
- Hydrophilic Polymers Enable Gastrointestinal Transit Monitoring by Fluorine-19 Magnetic Resonance Imaging.Advanced healthcare materials · 2026Article
- Spatial concordance metrics and related risk factors of brain-peripheral barrier axes: unveiling distinct concordance patterns for mental and neurological axes.Molecular psychiatry · 2026Article
- Assembled Hyaluronic Acid Therapeutics for Targeting M1 Macrophages and Regulating Immune Homeostasis for Ulcerative Colitis Treatment.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Supramolecular Zinc-Polyphenol Coordination Assemblies Mitigate Colonic Inflammation by Regulating Mucosal Barrier and Microbiome.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Microplastics and nanoplastics in inflammatory bowel disease: Mechanistic plausibility, human evidence and future research priorities.World journal of gastrointestinal pathophysiology · 2026Review
- The exposome and inflammatory bowel disease: a framework for primary and primordial prevention.Nature reviews. Gastroenterology & hepatology · 2026Review
- Global gut microbiome atlas identifies epidemiologic-stage-specific signatures in inflammatory bowel disease.Cell reports. Medicine · 2026Article
200 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
67 authors.
Lindsay Hracs *Division of Gastroenterology and Hepatology, Department of Medicine, University of Calgary, Calgary, Alberta, Canada.ORCID 0000-0002-8618-7544
Joseph W Windsor *Division of Gastroenterology and Hepatology, Department of Medicine, University of Calgary, Calgary, Alberta, Canada.ORCID 0000-0002-7539-9103
Julia GorospeDivision of Gastroenterology and Hepatology, Department of Medicine, University of Calgary, Calgary, Alberta, Canada.
Michael CummingsCentre for Health Informatics and Department of Community Health Sciences, University of Calgary, Calgary, Alberta, Canada.
Stephanie CowardDivision of Gastroenterology and Hepatology, Department of Medicine, University of Calgary, Calgary, Alberta, Canada.ORCID 0000-0003-0675-7226
Michael J BuieDivision of Gastroenterology and Hepatology, Department of Medicine, University of Calgary, Calgary, Alberta, Canada.ORCID 0000-0003-2909-9721
Joshua QuanDivision of Gastroenterology and Hepatology, Department of Medicine, University of Calgary, Calgary, Alberta, Canada.ORCID 0009-0008-8186-8827
Quinn GoddardDivision of Gastroenterology and Hepatology, Department of Medicine, University of Calgary, Calgary, Alberta, Canada.
Léa CaplanDivision of Gastroenterology and Hepatology, Department of Medicine, University of Calgary, Calgary, Alberta, Canada.ORCID 0000-0002-7973-5995
Ante MarkovinovićDivision of Gastroenterology and Hepatology, Department of Medicine, University of Calgary, Calgary, Alberta, Canada.ORCID 0009-0003-0212-0540
Tyler WilliamsonCentre for Health Informatics and Department of Community Health Sciences, University of Calgary, Calgary, Alberta, Canada.ORCID 0000-0001-5029-2345
Yvonne AbbeyMaidstone and Tunbridge Wells NHS Trust, Kent, UK.ORCID 0009-0002-1383-519X
Murdani AbdullahDivision of Gastroenterology, Department of Internal Medicine, HCRC IMERI, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia.
Maria T AbreuF. Widjaja Inflammatory Bowel Disease Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Vineet AhujaInternational Organization for the study of Inflammatory Bowel Disease (IOIBD), Stockholm, Sweden.
Raja Affendi Raja AliSir Jeffrey Cheah Sunway Medical School, Faculty of Medical and Life Sciences, Sunway University, Selangor, Malaysia.
Mansour AltuwaijriDivision of Gastroenterology, Department of Medicine, College of Medicine, King Saud University, Riyadh, Saudi Arabia.ORCID 0000-0001-7200-0702
Domingo BalderramoIBD Unit, Gastroenterology Department, Hospital Privado Universitario de Córdoba, Instituto Universitario de Ciencias Biomédicas de Córdoba, Córdoba, Argentina.ORCID 0000-0001-9598-2577
Rupa BanerjeeInternational Organization for the study of Inflammatory Bowel Disease (IOIBD), Stockholm, Sweden.
Eric I BenchimolSickKids Inflammatory Bowel Disease Centre, Division of Gastroenterology, Hepatology and Nutrition, The Hospital for Sick Children (SickKids), Toronto, Ontario, Canada.ORCID 0000-0001-8855-3598
Charles N BernsteinInternational Organization for the study of Inflammatory Bowel Disease (IOIBD), Stockholm, Sweden.ORCID 0000-0001-8041-3574
Eduard Brunet-MasGastroenterology Department, Parc Taulí Hospital Universitari, Institut d'Investigació I Innovació Parc Taulí (I3PT-CERCA), Sabadell, Spain.ORCID 0000-0001-8661-0608
Johan BurischInternational Organization for the study of Inflammatory Bowel Disease (IOIBD), Stockholm, Sweden.ORCID 0000-0002-3312-5139
Vui Heng ChongDivision of Gastroenterology and Hepatology, Department of Medicine, Raja Isteri Pengiran Anak Saleha (RIPAS) Hospital, Bandar Seri Begawan, Brunei Darussalam.
Iris DotanInternational Organization for the study of Inflammatory Bowel Disease (IOIBD), Stockholm, Sweden.
Usha DuttaDepartment of Gastroenterology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Sara El OualiDigestive Disease Institute, Cleveland Clinic Abu Dhabi, Abu Dhabi, UAE.ORCID 0000-0001-6153-1081
Angela ForbesDepartment of Medicine, University of Otago, Christchurch, New Zealand.ORCID 0000-0003-0186-5877
Anders ForssDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0002-1906-4982
Richard GearryInternational Organization for the study of Inflammatory Bowel Disease (IOIBD), Stockholm, Sweden.
Viet Hang DaoInternal Medicine Faculty, Hanoi Medical University, Hanoi, Vietnam.ORCID 0000-0002-3685-9496
Juanda Leo HartonoYong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Ida HilmiDivision of Gastroenterology, Department of Medicine, Faculty of Medicine, University Malaya, Kuala Lumpur, Malaysia.
Phoebe HodgesBlizard Institute, Barts & The London School of Medicine, Queen Mary University of London, London, UK.ORCID 0000-0002-7231-0804
Gareth-Rhys JonesUniversity of Edinburgh, Institute for Regeneration and Repair, Edinburgh, UK.ORCID 0000-0001-7355-2357
Fabián Juliao-BañosDepartment of Gastroenterology, Pablo Tobon Uribe Hospital, Medellín, Colombia.ORCID 0000-0002-8610-9925
Jamilya KaibullayevaJSC Research Institute of Cardiology and Internal Diseases of the Ministry of Health of the Republic of Kazakhstan, Astana, Republic of Kazakhstan.ORCID 0000-0002-0783-4441
Paul KellyBlizard Institute, Barts & The London School of Medicine, Queen Mary University of London, London, UK.ORCID 0000-0003-0844-6448
Taku KobayashiCenter for Advanced IBD Research and Treatment, Kitasato University Kitasato Institute Hospital, Tokyo, Japan.ORCID 0000-0002-2073-4234
Paulo Gustavo KotzeInternational Organization for the study of Inflammatory Bowel Disease (IOIBD), Stockholm, Sweden.ORCID 0000-0002-9632-6691
Peter L LakatosInternational Organization for the study of Inflammatory Bowel Disease (IOIBD), Stockholm, Sweden.ORCID 0000-0002-3948-6488
Charlie W LeesCentre for Genomics and Experimental Medicine (CGEM), Institute of Genetics & Cancer, University of Edinburgh, Edinburgh, UK.
Julajak LimsrivilaiDivision of Gastroenterology, Siriraj Hospital, Mahidol University, Bangkok, Thailand.ORCID 0000-0001-5867-0312
Bobby LoGastrounit, Medical Division, Copenhagen University Hospital-Amager and Hvidovre, Hvidovre, Denmark.ORCID 0000-0002-0252-9341
Edward V LoftusInternational Organization for the study of Inflammatory Bowel Disease (IOIBD), Stockholm, Sweden.ORCID 0000-0001-7199-6851
Jonas F LudvigssonDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0003-1024-5602
Joyce W Y MakDepartment of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China.ORCID 0000-0001-5221-7349
YingLei MiaoGastroenterology, The First Affiliated Hospital of Kunming Medical University, Kunming, China.ORCID 0000-0001-8193-5198
Ka Kei NgConde S. Januário Hospital, Macao SAR, China.ORCID 0000-0001-9156-2903
Shinji OkabayashiDepartment of Healthcare Epidemiology, School of Public Health in the Graduate School of Medicine, Kyoto University, Kyoto, Japan.ORCID 0000-0003-2683-9018
Ola OlénDivision of Clinical Epidemiology, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0002-5478-7019
Remo PanaccioneDivision of Gastroenterology and Hepatology, Department of Medicine, University of Calgary, Calgary, Alberta, Canada.ORCID 0000-0002-5247-940X
Mukesh Sharma PaudelDepartment of Gastroenterology, National Academy of Medical Sciences, Kathmandu, Nepal.ORCID 0000-0003-2727-4688
Abel Botelho QuaresmaUNOESC Curso de Medicina: Universidade do Oeste de Santa Catarina, Joaçaba, Brazil.ORCID 0000-0002-3985-7402
David T RubinInternational Organization for the study of Inflammatory Bowel Disease (IOIBD), Stockholm, Sweden.ORCID 0000-0001-5647-1723
Marcellus SimadibrataDivision of Gastroenterology, Department of Internal Medicine, HCRC IMERI, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia.ORCID 0000-0003-1131-5836
Yang SunGastroenterology, The First Affiliated Hospital of Kunming Medical University, Kunming, China.
Hidekazu SuzukiDivision of Gastroenteroloy and Hepatology, Department of Internal Medicine, Tokai University School of Medicine, Isehara, Japan.ORCID 0000-0002-8994-6163
Martin ToroHead of the Inflammatory Bowel Diseases Unit, HIGEA, Mendoza, Argentina.
Dan TurnerInternational Organization for the study of Inflammatory Bowel Disease (IOIBD), Stockholm, Sweden.ORCID 0000-0001-5160-868X
Beatriz IadeCooperativa de Servicios Médicos (COSEM), Montevideo, Uruguay.
Shu Chen WeiDepartment of Internal Medicine, National Taiwan University Hospital and College of Medicine, Taipei, Taiwan.ORCID 0000-0002-5017-5840
Jesus K Yamamoto-FurushoInflammatory Bowel Disease Clinic, Department of Gastroenterology, National Institute of Medical Sciences and Nutrition and National Autonomous University of Mexico (UNAM), Mexico City, Mexico.ORCID 0000-0002-5247-5812
Suk-Kyun YangDepartment of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.ORCID 0000-0003-2772-2575
Siew C NgInternational Organization for the study of Inflammatory Bowel Disease (IOIBD), Stockholm, Sweden. siewchienng@cuhk.edu.hk.ORCID 0000-0002-6850-4454
Gilaad G KaplanDivision of Gastroenterology and Hepatology, Department of Medicine, University of Calgary, Calgary, Alberta, Canada. ggkaplan@ucalgary.ca.ORCID 0000-0003-2719-0556
Global IBD Visualization of Epidemiology Studies in the 21st Century (GIVES-21) Research Group
Funding
No grant is acknowledged in the PubMed record.
Abstract
During the twentieth century, inflammatory bowel disease (IBD) was considered a disease of early industrialized regions in North America, Europe and Oceania
Indexed as
Global HealthInflammatory Bowel DiseasesAdultDisease ProgressionFemaleHistory, 20th CenturyHistory, 21st CenturyHumansIncidenceMaleMiddle AgedPrevalenceSpatio-Temporal Analysis
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
NCT07155148ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.