ArticleNature aging2025
KLRG1 identifies regulatory T cells with mitochondrial alterations that accumulate with aging.
Abstract read
In one paragraph
Article in Nature aging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed.
- Palmitic acid coordinates impaired visceral adipose ICOShi Treg-mediated immunosuppression and systemic metabolic disturbance during obesity.The Journal of clinical investigation · 2026Article
- Metabolic exhaustion and immune ageing in rheumatoid arthritis.Nature reviews. Rheumatology · 2026Review
- Extracellular vesicle transcriptomic analysis to investigate muscle adaptation in microgravity.iScience · 2026Article
- Multiparametric Flow Cytometry Panel for Characterization of Mouse T Cell Differentiation and NK Cell Maturation Following Inflammatory Challenge.Methods and protocols · 2026Article
- Regulation of T Cell Senescence in Health and Diseases.Immune network · 2026Review
- Aging mechanisms and rejuvenation strategies for hematopoietic stem cells.Genome biology · 2026Review
- Intestinal T cells in aging: implications for gut barrier integrity and inflammaging.GeroScience · 2026Review
- Immunosenescence and Bone Homeostasis: From Mechanisms of Homeostasis Disruption to Therapeutic Opportunities in Age-Related Skeletal Disorders.International journal of molecular sciences · 2026Review
- T Cell Immunosenescence in Inflammatory Skin Diseases: Pathogenesis and Therapeutic Targets.Aging cell · 2026Review
- CD8Science China. Life sciences · 2026Review
- TLR4 maintains Treg-mediated protection against adverse outcomes in a model of hepatic surgical stress.The Journal of clinical investigation · 2026Article
- Association between T cell exhaustion and the recurrence of atrial fibrillation after cryoballoon ablation.Frontiers in immunology · 2026Article
- Decoding Treg diversity and dysfunction to advance Treg-based therapies in autoimmune and inflammatory diseases.Frontiers in immunology · 2026Review
- IL-27 promotes Treg cell expression of CD122 and fitness at homeostasis.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Reading the immune clock: a machine learning model predicts mouse immune age from cellular patterns.Nature communications · 2025Article
- Heterogeneity of Cellular Senescence, Senotyping, and Targeting by Senolytics and Senomorphics in Lung Diseases.International journal of molecular sciences · 2025Review
- Immunosenescence and cancer: molecular hallmarks, tumor microenvironment remodeling, and age-specific immunotherapy challenges.Journal of hematology & oncology · 2025Review
- Systemic inflammation as a central player in the initiation and development of Alzheimer's disease.Immunity & ageing : I & A · 2025Review
- Aging reshapes the adaptive immune system from healer to saboteur.Nature aging · 2025Review
- CD4 T cell therapy counteracts inflammaging and senescence by preserving gut barrier integrity.Science immunology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
20 authors.
Gonzalo Soto-HerederoDepartamento de Biología Molecular, Facultad de Ciencias, Centro de Biología Molecular 'Severo Ochoa', Universidad Autónoma de Madrid, Madrid, Spain.ORCID http://orcid.org/0000-0001-8043-7314
Enrique Gabandé-RodríguezDepartamento de Biología Molecular, Facultad de Ciencias, Centro de Biología Molecular 'Severo Ochoa', Universidad Autónoma de Madrid, Madrid, Spain.ORCID http://orcid.org/0000-0002-9715-8714
Elisa CarrascoDepartamento de Biología, Facultad de Ciencias, Centro de Biología Molecular 'Severo Ochoa', Universidad Autónoma de Madrid, Madrid, Spain.ORCID http://orcid.org/0000-0002-0817-1627
José Ignacio Escrig-LarenaConsejo Superior de Investigaciones Científicas, Centro de Biología Molecular 'Severo Ochoa', Universidad Autónoma de Madrid, Madrid, Spain.ORCID http://orcid.org/0000-0002-1538-8808
Manuel M Gómez de Las HerasDepartamento de Biología Molecular, Facultad de Ciencias, Centro de Biología Molecular 'Severo Ochoa', Universidad Autónoma de Madrid, Madrid, Spain.ORCID http://orcid.org/0000-0001-7447-694X
Sandra Delgado-PulidoConsejo Superior de Investigaciones Científicas, Centro de Biología Molecular 'Severo Ochoa', Universidad Autónoma de Madrid, Madrid, Spain.ORCID http://orcid.org/0000-0003-2055-6594
Isaac Francos-QuijornaDepartamento de Biología Molecular, Facultad de Ciencias, Centro de Biología Molecular 'Severo Ochoa', Universidad Autónoma de Madrid, Madrid, Spain.
Eva M BlancoConsejo Superior de Investigaciones Científicas, Centro de Biología Molecular 'Severo Ochoa', Universidad Autónoma de Madrid, Madrid, Spain.ORCID http://orcid.org/0000-0001-5940-1827
Álvaro Fernández-AlmeidaConsejo Superior de Investigaciones Científicas, Centro de Biología Molecular 'Severo Ochoa', Universidad Autónoma de Madrid, Madrid, Spain.ORCID http://orcid.org/0009-0006-1483-4585
David AbiaConsejo Superior de Investigaciones Científicas, Centro de Biología Molecular 'Severo Ochoa', Universidad Autónoma de Madrid, Madrid, Spain.ORCID http://orcid.org/0000-0003-0401-7590
María Josefa RodríguezServicio de Microscopía Electrónica, Centro de Biología Molecular 'Severo Ochoa', Universidad Autónoma de Madrid, Madrid, Spain.
Cristina M Fernández-DíazIMDEA Food Institute, CEI UAM+CSIC, Madrid, Spain.
María Beatriz Álvarez-FloresCentro Nacional de Investigaciones Cardiovasculares, Instituto de Salud Carlos III, Madrid, Spain.ORCID http://orcid.org/0000-0002-0292-5010
Ana Ramírez de MolinaIMDEA Food Institute, CEI UAM+CSIC, Madrid, Spain.
Sascha JungLuxembourg Centre for Systems Biomedicine, University of Luxembourg, Esch sur-Alzette, Luxembourg.
Antonio Del SolLuxembourg Centre for Systems Biomedicine, University of Luxembourg, Esch sur-Alzette, Luxembourg.ORCID http://orcid.org/0000-0002-9926-617X
Virginia ZoritaCentro Nacional de Investigaciones Cardiovasculares, Instituto de Salud Carlos III, Madrid, Spain.
Fátima Sánchez-CaboCentro Nacional de Investigaciones Cardiovasculares, Instituto de Salud Carlos III, Madrid, Spain.
Carlos TorrojaCentro Nacional de Investigaciones Cardiovasculares, Instituto de Salud Carlos III, Madrid, Spain.ORCID http://orcid.org/0000-0001-8914-3400
María MittelbrunnConsejo Superior de Investigaciones Científicas, Centro de Biología Molecular 'Severo Ochoa', Universidad Autónoma de Madrid, Madrid, Spain. mmittelbrunn@cbm.csic.es.ORCID http://orcid.org/0000-0003-3487-8762
Funding
Comunidad de Madrid NutriSION-CM synergy grant Y2020/BIO-6350Comunidad de Madrid NutriSION-CM synergy grant Y2020/BIO-6350; PIPF-2022/SAL-GL-25208EC | EU Framework Programme for Research and Innovation H2020 | H2020 Priority Excellent Science | H2020 European Research Council (H2020 Excellent Science - European Research Council) 101044248-LetTBeMinistry of Economy and Competitiveness | Consejo Superior de Investigaciones Científicas (Spanish National Research Council) PID2022-141169OB-I00; PID2022-138295OB-I00Ministry of Economy and Competitiveness | Consejo Superior de Investigaciones Científicas (Spanish National Research Council) PID2022-141169OB-I00; PID2022-138295OB-I00; FPU19/02576Ministry of Economy and Competitiveness | Consejo Superior de Investigaciones Científicas (Spanish National Research Council) PID2022-141169OB-I00; PID2022-138295OB-I00; FPU20/04066
Abstract
Recent studies using single-cell RNA sequencing technology have uncovered several subpopulations of CD4
Indexed as
AgingLectins, C-TypeMitochondriaReceptors, ImmunologicT-Lymphocytes, RegulatoryAnimalsCellular SenescenceFemaleFlow CytometryHumansMaleMiceMice, Inbred C57BLSingle-Cell AnalysisKLRG1 protein, humanKlrg1 protein, mouseLectins, C-TypeReceptors, Immunologic
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.