Evidence map›Paper›PMID 40307481›Full record

ArticleScientific reports2025

Surgical considerations towards inducing proprioceptive feedback in dental implants.

Siddhartha Das, Subhashis Ghosh, Qisheng Tu, Zoe Xiaofang Zhu, Jake Jinkun Chen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. An Implanted Tooth That Can Feel.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Siddhartha DasBasic and Clinical Translational Sciences, Tufts Graduate School of Biomedical Sciences, Tufts University School of Medicine, 136 Harrison Ave, M&V Room 830, Boston, MA, 02111, USA.
Subhashis GhoshBasic and Clinical Translational Sciences, Tufts Graduate School of Biomedical Sciences, Tufts University School of Medicine, 136 Harrison Ave, M&V Room 830, Boston, MA, 02111, USA.
Qisheng TuBasic and Clinical Translational Sciences, Tufts Graduate School of Biomedical Sciences, Tufts University School of Medicine, 136 Harrison Ave, M&V Room 830, Boston, MA, 02111, USA. qisheng.tu@tufts.edu.
Zoe Xiaofang ZhuBasic and Clinical Translational Sciences, Tufts Graduate School of Biomedical Sciences, Tufts University School of Medicine, 136 Harrison Ave, M&V Room 830, Boston, MA, 02111, USA.
Jake Jinkun ChenBasic and Clinical Translational Sciences, Tufts Graduate School of Biomedical Sciences, Tufts University School of Medicine, 136 Harrison Ave, M&V Room 830, Boston, MA, 02111, USA. jk.chen@tufts.edu.

Funding

Roles of Noncoding RNA in Bone RegenerationR01DE025681 · NIDCR · TUFTS UNIVERSITY BOSTON · PI CHEN, JAKE JINKUN · 2016 to 2024
$4.5M
A Long Noncoding RNA Amerliorates Periodontitis via Distinct Epigenetic PathwaysR01DE030074 · NIDCR · TUFTS UNIVERSITY BOSTON · PI CHEN, JAKE JINKUN · 2021 to 2025
$3.5M
Therapeutic Potentials of a New Long Noncoding RNA in Diabetic Bone Wound RepairR01DK131444 · NIDDK · TUFTS UNIVERSITY BOSTON · PI JAKE JINKUN CHEN · 2022 to 2026
$2.4M
Potentials of Epigenetic Molecules in Attenuating the Phenotypes of PeriodontitisR01DE032006 · NIDCR · TUFTS UNIVERSITY BOSTON · PI JAKE JINKUN CHEN · 2023 to 2026
$2.0M
NIDCR NIH HHS R01 DE025681NIDCR NIH HHS R01 DE030074NIDCR NIH HHS R01 DE032006NIDDK NIH HHS R01 DK131444NIH HHS DK131444, DE30074, DE25681 and DE32006
6 · The paper itself

Abstract

Periodontal ligament (PDL) consists mainly of collagen fiber bundles with specialized mechanoreceptors and free nerve endings that connect the cementum of the tooth root to alveolar bone and are vital for dental proprioceptive function. When a tooth is lost and replaced with a dental implant, osseointegration occurs without the intervening PDL, leading to a loss of proprioceptive function. Herein we report the placement, and healthy integration of an advanced dental implant in the socket of rat study models without facilitating the process of osseointegration, that could possibly impart proprioceptive features comparable to those noted in natural teeth. The experimental surgical procedure during dental implant installation in rat models involved various oral tissue structures surrounding the teeth as analogous to those in human subjects and therefore bears a significant clinical relevance. Additionally, the surgical procedure detailed here confers the advantages of its use to investigate not only dental implants but also could be explorative for a wide range of extra-oral implants for improved neural integration.

Indexed as

Dental Implantation, EndosseousDental ImplantsPeriodontal LigamentProprioceptionAnimalsHumansMaleOsseointegrationRatsDental ImplantsExperimental surgeryPress-fit dental implantsRat study modelsTitanium dental implant

Identifiers

PMID40307481
PMCPMC12043845

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.