Evidence map›Paper›PMID 40307408›Full record

ArticleNature ecology & evolution2025

Simulated early Earth geochemistry fuels a hydrogen-dependent primordial metabolism.

Vanessa Helmbrecht, Robert Reichelt, Dina Grohmann, William D Orsi

Abstract read
In one paragraph

Article in Nature ecology & evolution, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Lithosyntrophy: Obligate syntrophy in a phosphite-oxidizing, methanogenic culture.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  4. Article
  5. Article
  6. Frontiers in microbiology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Vanessa HelmbrechtDepartment of Earth and Environmental Sciences, Ludwig-Maximilians-Universität München, Munich, Germany.ORCID http://orcid.org/0000-0002-7537-3798
Robert ReicheltInstitute of Biochemistry, Genetics and Microbiology, Institute of Microbiology and Archaea Centre, Single-Molecule Biochemistry Lab and Regensburg Center for Biochemistry, University of Regensburg, Regensburg, Germany.
Dina GrohmannInstitute of Biochemistry, Genetics and Microbiology, Institute of Microbiology and Archaea Centre, Single-Molecule Biochemistry Lab and Regensburg Center for Biochemistry, University of Regensburg, Regensburg, Germany.
William D OrsiDepartment of Earth and Environmental Sciences, Ludwig-Maximilians-Universität München, Munich, Germany. w.orsi@lrz.uni-muenchen.de.ORCID http://orcid.org/0000-0002-4094-5637

Funding

Deutsche Forschungsgemeinschaft (German Research Foundation) OR 417/8-1
6 · The paper itself

Abstract

Molecular hydrogen is the electron donor for the ancient exergonic reductive acetyl-coenzyme A pathway (acetyl-CoA pathway), which is used by hydrogenotrophic methanogenic archaea. How the presence of iron-sulfides influenced the acetyl-CoA pathway under primordial early Earth geochemistry is still poorly understood. Here we show that the iron-sulfides mackinawite (FeS) and greigite (Fe

Indexed as

HydrogenMethanocaldococcusAcetyl Coenzyme AEarth, PlanetIronMethaneSulfidesAcetyl Coenzyme AHydrogenIronMethaneSulfides

Identifiers

PMID40307408
PMCPMC12066356

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.