Evidence map›Paper›PMID 40307407›Full record

ArticleScientific reports2025

Knowledge and practice of healthy behaviors for dementia and stroke prevention in a United States cohort.

Jasper R Senff, Reinier W P Tack, Benjamin Y Q Tan, Savvina Prapiadou, Tamara N Kimball, Sharon Ng, Jonathan Duskin, Mark Jun Shah-Ostrowski, Courtney Nunley, H Bart Brouwers and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Jasper R SenffBrain Care Labs, Massachusetts General Hospital, Boston, MA, USA. jasper_senff@hotmail.com.
Reinier W P TackBrain Care Labs, Massachusetts General Hospital, Boston, MA, USA.
Benjamin Y Q TanBrain Care Labs, Massachusetts General Hospital, Boston, MA, USA.
Savvina PrapiadouBrain Care Labs, Massachusetts General Hospital, Boston, MA, USA.
Tamara N KimballBrain Care Labs, Massachusetts General Hospital, Boston, MA, USA.
Sharon NgBrain Care Labs, Massachusetts General Hospital, Boston, MA, USA.
Jonathan DuskinBrain Care Labs, Massachusetts General Hospital, Boston, MA, USA.
Mark Jun Shah-OstrowskiNuffield Department of Population Health, University of Oxford, Oxford, UK.
Courtney NunleyBrain Care Labs, Massachusetts General Hospital, Boston, MA, USA.
H Bart BrouwersDepartment of Neurology and Neurosurgery, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands.
Zeina ChemaliBrain Care Labs, Massachusetts General Hospital, Boston, MA, USA.
Gregory FricchioneBrain Care Labs, Massachusetts General Hospital, Boston, MA, USA.
Rudolph E TanziDepartment of Neurology, Massachusetts General Hospital, Boston, MA, USA.
Koen PouwelsNuffield Department of Population Health, University of Oxford, Oxford, UK.
Jonathan RosandBrain Care Labs, Massachusetts General Hospital, Boston, MA, USA.
Nirupama YechoorBrain Care Labs, Massachusetts General Hospital, Boston, MA, USA.
Christopher D AndersonBrain Care Labs, Massachusetts General Hospital, Boston, MA, USA.
Sanjula D SinghBrain Care Labs, Massachusetts General Hospital, Boston, MA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

At least 45% of dementia and 60% of stroke cases are due to modifiable risk factors and could in part be prevented through healthy behavior. This cross-sectional study clustered and characterized a U.S. cohort's knowledge and practice of healthy behavior associated with dementia and stroke. A total of 1,478 participants (mean age: 45.5 years, 51.8% female) were included. A hierarchical cluster analysis was performed to identify clusters based on the level of knowledge and practice of healthy behavior. We defined knowledge as recognizing eight modifiable risk factors (alcohol, diet, smoking, physical activity, sleep, stress, social relationships, and purpose in life) as important. We defined practice as complying with validated recommendations for each healthy behavior. Three clusters emerged: (I) high knowledge and poor practice (II) high knowledge and good practice, and (III) lower knowledge and poor practice. Participants in the high knowledge and good practice cluster were statistically significantly older, more educated, perceived fewer barriers (financial and time limitations), and more facilitators (motivation or knowing someone with dementia or stroke) compared to the other clusters. Our findings could assist in tailoring preventative strategies to enhance knowledge, translating knowledge into practice, and addressing particular facilitators and barriers per identified cluster.

Indexed as

DementiaHealth BehaviorHealth Knowledge, Attitudes, PracticeStrokeAdultAgedCluster AnalysisCohort StudiesCross-Sectional StudiesFemaleHumansMaleMiddle AgedRisk FactorsUnited StatesDementiaHealthy behaviorsKnowledgePracticePreventionStroke

Identifiers

PMID40307407
PMCPMC12044067

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.