ArticleEye (London, England)2025
Characteristics of orbital lymphoproliferative disorders: a retrospective study of 84 cases.
Article in Eye (London, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Extranodal MALT lymphoma masquerading as a cavernous hemangioma: A diagnostic and surgical challenge.Radiology case reports · 2026Article
- Unilateral Orbital Lymphomas: A Structured Multidisciplinary Workflow for Diagnosis and Management.Clinical ophthalmology (Auckland, N.Z.) · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo investigate the variations in clinical presentation, imaging characteristics, and immunohistochemical features between benign and malignant orbital lymphoproliferative disorders (OLPDs).
methodsAt the Eye Center of the First Affiliated Hospital, Zhejiang University School of Medicine, a retrospective analysis was performed on the clinical records of all patients diagnosed with OLPDs from 2014 to 2022. This study included a comparative analysis between patients diagnosed with benign and malignant OLPDs.
resultsA total of 84 patients were included in this research, with a mean age of 62.24 ± 14.52 years and male-to-female ratio of 43:41. The pathological types comprised benign orbital lymphoproliferative tumours (26/84, 31%, mean age 59.31 ± 10.4 years, male-to-female ratio of 16:10) and malignant orbital lymphomas (58/84, 69%, mean age 63.55 ± 15.93 years, male-to-female ratio of 27:31). The most common symptoms in benign and malignant OLPDs were palpable mass and eyelid swelling. Typically, malignant orbital lymphoma masses exhibited low signal intensity on T1-weighted imaging (T1WI), whereas benign lymphoproliferative tumours commonly demonstrated iso-intensity on T1WI. Notably, the expression of cluster of differentiation 3, 5, 10, 23, 43, and human immunoglobulin light chain lambda demonstrated statistically significant differences between the benign and malignant OLPD groups.
conclusionBenign and malignant OLPDs exhibit similar clinical presentations and imaging characteristics. Currently, distinguishing between benign and malignant OLPDs still requires pathological biopsy. Research on specialized imaging techniques and specific biomarkers for malignant orbital lymphomas is underway, showing potential for enhancing the accuracy of non-invasive diagnoses for benign and malignant OLPDs.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.