Evidence map›Paper›PMID 40307384›Full record

ArticleScientific reports2025

Heteronymous feedback from quadriceps onto soleus is influenced by limb loading and task context.

Mark A Lyle, Steven L Wolf, Cristian Cuadra

Abstract read
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Mark A LyleDivision of Physical Therapy, Department of Rehabilitation Medicine, Center for Physical Therapy and Movement Science, Emory University School of Medicine, Atlanta, GA, USA. mark.lyle@emory.edu.ORCID http://orcid.org/0000-0002-0954-0447
Steven L WolfDivision of Physical Therapy, Department of Rehabilitation Medicine, Center for Physical Therapy and Movement Science, Emory University School of Medicine, Atlanta, GA, USA.
Cristian CuadraDepartment of Rehabilitation Science, University at Buffalo, Buffalo, NY, USA. ccuadra@buffalo.edu.ORCID http://orcid.org/0000-0002-9603-6993

Funding

Functional Role of Golgi tendon organ feedback in health and diseaseK01HD100588 · NICHD · EMORY UNIVERSITY · PI LYLE, MARK A · 2019 to 2023
$645k
NICHD NIH HHS K01 HD100588
6 · The paper itself

Abstract

Heteronymous reflexes from quadriceps can increase and/or decrease soleus activity; yet few studies have examined factors influencing reflex strength. This study examined the independent influence of limb loading, posture, and task context on heteronymous feedback from quadriceps onto soleus. The influence of limb loading and posture was determined by comparing femoral nerve elicited heteronymous excitation and inhibition of soleus in a semi-recumbent position with and without 50% body weight limb loading and while standing with back support (n = 16). Task context was examined by comparing heteronymous reflex magnitudes while standing with back support to maintaining an unsupported squat posture which requires tonic soleus activity to maintain the posture (n = 12). Heteronymous inhibition decreased by 20% with limb loading in both semi-recumbent and standing postures, while excitation remained unchanged suggesting that limb loading, rather than postural orientation, independently modulates heteronymous inhibition. Inhibition decreased by 50% and excitation by 90% when maintaining the squat posture compared to supported standing. The pronounced suppression of both excitation and inhibition during the squat is considered a task-appropriate reflex modulation that aids in maintaining the posture. The results of this study highlight an important modulatory influence of limb loading afferents and task context on heteronymous reflex circuits.

Indexed as

Feedback, PhysiologicalMuscle, SkeletalQuadriceps MuscleReflexAdultElectromyographyFemaleFemoral NerveHumansMalePostureWeight-BearingYoung AdultFemoral nerveHeteronymous reflexLimb loadingProprioceptive feedbackTask modulation

Identifiers

PMID40307384
PMCPMC12043819

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.