ArticleScientific reports2025
Green synthesis of a lactoferrin-infused silver nanoparticle gel for enhanced wound healing.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Lactoferrin-Templated Silver Peroxide Nanoparticles Reinforced Core-Shell Microneedle for Diabetic Infected Wound Sequential Therapy.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- Targeting Pathogenic Infection and Virulence Genes of Enterococcus Faecalis Using Lactoferrin Bismuth Nano-form.Probiotics and antimicrobial proteins · 2026Article
- Platelet Lysate-Based Biomaterials for Regenerative Tissue Engineering: A Comprehensive Review.International journal of nanomedicine · 2026Review
- Application of Bioactive Natural Compounds to Promote Cell Proliferation and Migration in the Wound Healing Process.Results and problems in cell differentiation · 2026Review
- Tri-layer structured intelligent hydrogel dressing for controlled-release antibacterial treatment of chronic diabetic wounds.RSC advances · 2025Article
- Recent Advances of Silver Nanoparticles in Wound Healing: Evaluation of In Vivo and In Vitro Studies.International journal of molecular sciences · 2025Review
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Authors and funding
5 authors.
Funding
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Abstract
The study analyzed the benefits of nano-silver (AgNPs) in reducing side effects and enhancing efficacy, highlighting the advantages compared to silver ions. The study examined the production of AgNPs-lactoferrin complexes (AgNPs-LTF) using bovine lactoferrin (LTF) at 1, 2, and 4 mM concentrations. The objective was to create an AgNPs-LTF gel with Carbopol as the base and assess its effectiveness in enhancing wound healing in rats. UV-Vis, PL, FTIR, and XRD analyses confirmed the synthesis of AgNPs. Microscopic examinations (TEM and SEM) showed mainly spherical AgNPs in the AgNPs-LTF samples, with diameters between 11 and 27 nm. The AgNPs-LTF gel with biologically processed AgNPs demonstrated effective infection control and enhanced wound healing outcomes. In Sprague-Dawley rats, the 4 mM AgNPs-LTF gel demonstrated significant wound closure, achieving complete closure by day 10, exceeding the healing rates of both the LTF and control groups. The AgNPs-LTF complex demonstrated high robustness and exceeded the performance of native LTF, exhibiting similar toxicity levels to AgNPs. The study shows the effectiveness of AgNPs-LTF gel in wound treatment, indicating its potential as a viable treatment option.
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Registered trials
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