Evidence map›Paper›PMID 40307324›Full record

ArticleScientific reports2025

Therapeutic mechanistic study of novel indole derivatives as SIRTUIN3 modulators in Parkinson's disease with in vitro evaluation.

Jagdish Chand, Srikanth Jupudi, Sheikh F Ahmad, Talha Bin Emran, Gomathy Subramanian

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jagdish ChandDepartment of Pharmaceutical Chemistry, JSS College of Pharmacy, JSS Academy of Higher Education & Research, Ooty, The Nilgiris, Tamil Nadu, 643001, India. sachinchand190@gmail.com.
Srikanth JupudiDepartment of Pharmaceutical Chemistry, JSS College of Pharmacy, JSS Academy of Higher Education & Research, Ooty, The Nilgiris, Tamil Nadu, 643001, India.
Sheikh F AhmadDepartment of Pharmacology and Toxicology, College of Pharmacy, King Saud University, 11451, Riyadh, Saudi Arabia.
Talha Bin EmranDepartment of Pathology and Laboratory Medicine, Warren Alpert Medical School, Brown University, Providence, RI, 02912, USA.
Gomathy SubramanianDepartment of Pharmaceutical Chemistry, JSS College of Pharmacy, JSS Academy of Higher Education & Research, Ooty, The Nilgiris, Tamil Nadu, 643001, India. gomathys@jssuni.edu.in.

Funding

King Saud University, Riyadh, Saudi Arabia RSPD2025R709
6 · The paper itself

Abstract

SIRT3 modulates reactive oxygen species and helps to reduce oxidative stress, resulting in a neuroprotective effect in Parkinson's disease. The work seeks to develop and synthesize novel, effective SIRT3 modulators, which will modify SIRT3 expression and generate the neuroprotective effect by downregulating reactive oxygen species. The synthesis of the new indole-based carboxamide derivatives IMW 1-16 was guided by molecular docking experiments with the SIRT3 wild-type protein. FT-IR,

Indexed as

IndolesNeuroprotective AgentsParkinson DiseaseSirtuin 3AnimalsHumansMembrane Potential, MitochondrialMolecular Docking SimulationOxidative StressReactive Oxygen SpeciesSuperoxide DismutaseIndolesNeuroprotective AgentsReactive Oxygen SpeciesSIRT3 protein, humanSirtuin 3Superoxide DismutaseIndole derivativesMolecular dockingParkinson’s diseaseSHSY-5Y neuroblastoma cell linesSIRT3

Identifiers

PMID40307324
PMCPMC12044002

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.