ArticleScientific reports2025
One-pot three-component synthesis of azaspirononatriene derivatives.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The present investigation has introduced a new class of isocyanide/acetylene-based multicomponent reactions (IAMCRs). These are a robust technique for efficiently synthesizing intricate spiro architectures through a zwitterionic adduct. The coupling reaction between the "in situ" generated dipoles of the isocyanide-acetylenic ester adducts and 3-alkyl-4-arylidene-isoxazol-5(4H)-one derivative presents a highly effective synthetic pathway for obtaining novel 1-oxo-2-oxa-3-azaspiro[4.4]nona-3,6,8-triene heterocycles. The broad range of substrates, standard experimental conditions, straightforward procedure, and impressive yields make our catalyst-free three-component approach highly practical and green, as it remarkably offers step-, time- and cost-effectiveness based on the green metrics.
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