Evidence map›Paper›PMID 40307231›Full record

ArticleNature communications2025

The motor neuron m6A repertoire governs neuronal homeostasis and FTO inhibition mitigates ALS symptom manifestation.

Ya-Ping Yen, Ting-Hsiang Lung, Ee Shan Liau, Chuan-Che Wu, Guan-Lin Huang, Fang-Yu Hsu, Mien Chang, Zheng-Dao Yang, Chia-Yi Huang, Zhong Zheng and 5 more

Abstract read
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
  2. mNature reviews. Neuroscience · 2026
    Review
  3. Review
  4. The Role of NMedComm · 2026
    Review
  5. FTO-modulated mJournal of translational medicine · 2026
    Article
  6. Article
  7. Review
  8. Review
  9. Article
  10. Molecular Visualization of Neuronal TDP43 PathologybioRxiv : the preprint server for biology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Ya-Ping YenInstitute of Molecular Biology, Academia Sinica, Taipei, Taiwan. yapingyen@gate.sinica.edu.tw.ORCID http://orcid.org/0000-0003-2264-8126
Ting-Hsiang LungInstitute of Molecular Biology, Academia Sinica, Taipei, Taiwan.ORCID http://orcid.org/0009-0005-1324-0657
Ee Shan LiauInstitute of Molecular Biology, Academia Sinica, Taipei, Taiwan.ORCID http://orcid.org/0000-0002-4115-5573
Chuan-Che WuInstitute of Molecular Biology, Academia Sinica, Taipei, Taiwan.ORCID http://orcid.org/0000-0002-6948-247X
Guan-Lin HuangInstitute of Molecular Biology, Academia Sinica, Taipei, Taiwan.ORCID http://orcid.org/0009-0004-7282-8541
Fang-Yu HsuInstitute of Molecular Biology, Academia Sinica, Taipei, Taiwan.ORCID http://orcid.org/0000-0002-0633-9529
Mien ChangInstitute of Molecular Biology, Academia Sinica, Taipei, Taiwan.
Zheng-Dao YangDepartment of Computer Science, National Yang Ming Chiao Tung University, Hsinchu City, Taiwan.
Chia-Yi HuangDepartment of Computer Science, National Yang Ming Chiao Tung University, Hsinchu City, Taiwan.
Zhong ZhengDepartment of Chemistry and Institute for Biophysical Dynamics, University of Chicago, Chicago, IL, USA.
Wei ZhaoDepartment of Mathematics, NSF-Simons Center for Multiscale Cell Fate Research, Department of Developmental and Cell Biology, University of California, Irvine, Irvine, CA, USA.ORCID http://orcid.org/0000-0003-1241-5652
Jui-Hung HungDepartment of Computer Science, National Yang Ming Chiao Tung University, Hsinchu City, Taiwan.ORCID http://orcid.org/0000-0003-2208-9213
Chuan HeDepartment of Chemistry and Institute for Biophysical Dynamics, University of Chicago, Chicago, IL, USA.ORCID http://orcid.org/0000-0003-4319-7424
Qing NieDepartment of Mathematics, NSF-Simons Center for Multiscale Cell Fate Research, Department of Developmental and Cell Biology, University of California, Irvine, Irvine, CA, USA.
Jun-An ChenInstitute of Molecular Biology, Academia Sinica, Taipei, Taiwan. jac2210@gate.sinica.edu.tw.ORCID http://orcid.org/0000-0001-9870-3203

Funding

Academia Sinica AS-GCP-113-L02National Health Research Institutes (NHRI) NHRI-EX113-11330NI
6 · The paper itself

Abstract

Amyotrophic lateral sclerosis (ALS) is a swiftly progressive and fatal neurodegenerative ailment marked by the degenerative motor neurons (MNs). Why MNs are specifically susceptible in predominantly sporadic cases remains enigmatic. Here, we demonstrated N

Indexed as

AdenosineAlpha-Ketoglutarate-Dependent Dioxygenase FTOAmyotrophic Lateral SclerosisMethyltransferasesMotor NeuronsAnimalsDisease Models, AnimalFemaleHomeostasisHumansInduced Pluripotent Stem CellsMaleMethylationMiceMice, KnockoutAdenosineAlpha-Ketoglutarate-Dependent Dioxygenase FTOFTO protein, humanFTO protein, mouseMethyltransferasesMETTL14 protein, humanMettl14 protein, mouseMettl3 protein, mouseN-methyladenosine

Identifiers

PMID40307231
PMCPMC12043976

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.