Evidence map›Paper›PMID 40307229›Full record

ArticleNature communications2025

METTL14 regulates chondrogenesis through the GDF5-RUNX-extracellular matrix gene axis during limb development.

Nobuko Katoku-Kikyo, Hiroko Kawakami, Max Cantor, Yasuhiko Kawakami, Nobuaki Kikyo

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Examining the Roles of mBio-protocol · 2025
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Nobuko Katoku-KikyoStem Cell Institute, University of Minnesota, Minneapolis, MN, USA.ORCID http://orcid.org/0000-0001-8204-6667
Hiroko KawakamiStem Cell Institute, University of Minnesota, Minneapolis, MN, USA.
Max CantorStem Cell Institute, University of Minnesota, Minneapolis, MN, USA.ORCID http://orcid.org/0009-0004-6384-7169
Yasuhiko KawakamiStem Cell Institute, University of Minnesota, Minneapolis, MN, USA. kawak005@umn.edu.ORCID http://orcid.org/0000-0002-0043-9705
Nobuaki KikyoStem Cell Institute, University of Minnesota, Minneapolis, MN, USA. kikyo001@umn.edu.ORCID http://orcid.org/0000-0002-5817-4498

Funding

Genetic Regulation of Progenitor Cells in Appendicular Skeletal DevelopmentR01AR064195 · NIAMS · UNIVERSITY OF MINNESOTA · PI KAWAKAMI, YASUHIKO · 2013 to 2022
$3.3M
RNA methylation and mesenchymal stem cell differentiationR01GM137603 · NIGMS · UNIVERSITY OF MINNESOTA · PI KIKYO, NOBUAKI · 2020 to 2023
$1.4M
NIAMS NIH HHS R01 AR064195NIGMS NIH HHS R01 GM137603U.S. Department of Health & Human Services | NIH | National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) R01AR064195U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) R01GM137603
6 · The paper itself

Abstract

m

Indexed as

ChondrogenesisCore Binding Factor Alpha 1 SubunitCore Binding Factor Alpha 3 SubunitExtracellular MatrixExtremitiesGrowth Differentiation Factor 5MethyltransferasesAnimalsCartilageGene Expression Regulation, DevelopmentalHumansLimb BudsMiceMice, KnockoutCore Binding Factor Alpha 1 SubunitCore Binding Factor Alpha 3 SubunitGdf5 protein, mouseGrowth Differentiation Factor 5MethyltransferasesRunx2 protein, mouseRunx3 protein, mouse

Identifiers

PMID40307229
PMCPMC12043825

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.