Cathodic oxygen reduction-enabled rhodium-catalyzed (5 + 1) C-H/O-H annulation inspired by fuel cells.

Yuan-Qiong Huang, Li Zhu, Tian-Sheng Mei

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Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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0 citing papers in PubMed.

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5 · Who and what money

Authors and funding

3 authors.

Yuan-Qiong Huang *State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, CAS, Shanghai, China.

Li Zhu *State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, CAS, Shanghai, China.

Tian-Sheng MeiState Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, CAS, Shanghai, China. mei7900@sioc.ac.cn.ORCID http://orcid.org/0000-0002-4985-1071

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Transition metal-catalyzed electrochemical C-H annulation with alkynes has emerged as a promising method for constructing heterocycles via formal cycloadditions. However, catalytic electrochemical C-H annulation with alkenes has been less explored. In this study, we report a cathodic oxygen reduction-enabled rhodium catalyzed (5 + 1) annulation reaction between readily available alkenylphenols and alkenes, yielding valuable 2-substituted 2H-chromenes. Unlike existing methods that involve direct oxidation of catalysts at the anode, our protocol uses a sacrificial anode to protect the substrate from overoxidation, while the cathode reduces oxygen, coupling with the Rh

Identifiers

PMID40307225

DOI10.1038/s41467-025-59405-x

PMCPMC12043932

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