ReviewTrends in neurosciences2025
Mechanical stress connects cortical folding to fiber organization in the developing brain.
Review in Trends in neurosciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Noninvasive 3D mapping of tissue stress using reverberant shear wave.Nature communications · 2026Article
- Biophysical modeling of anatomically realistic prenatal cortical folding development.Nature communications · 2026Article
- Neuromechanobiology: Bridging Mechanobiology and Neuroscience Through Evidence and Open Questions.Cells · 2026Review
- How do infant brains fold? Sulcal deepening is linked to development of sulcal span, thickness, curvature, and microstructure.Communications biology · 2026Article
- Biophysical modeling of anatomically realistic prenatal cortical folding development.Research square · 2026Article
- Sulcal Widening in Schizophrenia Maps onto Sulcal Hubs and Energy-Synaptic Genes.bioRxiv : the preprint server for biology · 2026Article
- Differential patterns of cortical expansion in fetal and preterm brain development.bioRxiv : the preprint server for biology · 2025Article
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Authors and funding
3 authors.
Funding
Abstract
During development of the gyrencephalic brain, both the formation of cortical folds and the establishment of axonal tracts require large, coordinated mechanical deformations. Cortical folding enables a high ratio of cortical surface area to brain volume, which is thought to enhance overall processing power. Meanwhile, a complex network of axonal connections facilitates communication between distant brain regions. The mechanisms underlying the formation of brain folds and axon tract organization remain widely debated. However, evidence emerging from measurements of mechanical stress, combined with physical and mathematical models, suggests that constrained cortical expansion generates folds via mechanical instability. In this opinion article, we highlight recent models and experimental data suggesting that mechanical stress induced by cortical folding also mediates axonal growth. We propose a key role for mechanics in establishing brain morphology and the organization of white matter fascicles of the mature brain.
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