Evidence map›Paper›PMID 40306968›Full record

ArticleJournal of nuclear medicine : official publication, Society of Nuclear Medicine2025

In Vivo Visualization and Quantification of Brain Heat Shock Protein 90 with [

Romy Cools, Koen Vermeulen, Eline Vonck, Veerle Baekelandt, Cassis Varlow, Valeria Narykina, Christopher Cawthorne, Koen Van Laere, Wim Vanduffel, Neil Vasdev and 1 more

Abstract read
In one paragraph

Article in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. FirstResearch square · 2026
    Article
  2. Article
  3. Review
  4. Review
  5. [EJNMMI radiopharmacy and chemistry · 2025
    Article
  6. Review
  7. Review
  8. Radiosynthesis and Evaluation of [Journal of labelled compounds & radiopharmaceuticals · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Romy CoolsLaboratory for Radiopharmaceutical Research, Department of Pharmacy and Pharmacologic Sciences, KU Leuven, Leuven, Belgium.
Koen VermeulenNuclear Medical Applications Institute, Belgian Nuclear Research Centre, Mol, Belgium.
Eline VonckLaboratory for Neurobiology and Gene Therapy, Leuven Brain Institute, KU Leuven, Leuven, Belgium.
Veerle BaekelandtLaboratory for Neurobiology and Gene Therapy, Leuven Brain Institute, KU Leuven, Leuven, Belgium.
Cassis VarlowBrain Health Imaging Centre, Centre for Addiction and Mental Health and University of Toronto, Toronto, Canada.
Valeria NarykinaSwitch Laboratory, Department of Cellular and Molecular Medicine, VIB-KU Leuven, Leuven, Belgium.
Christopher CawthorneNuclear Medicine and Molecular Imaging, Department of Imaging and Pathology, KU Leuven, Leuven, Belgium; and.
Koen Van LaereNuclear Medicine and Molecular Imaging, Department of Imaging and Pathology, KU Leuven, Leuven, Belgium; and.
Wim VanduffelLaboratory for Neuro- and Psychophysiology, Department of Neuroscience, KU Leuven, Leuven, Belgium.
Neil VasdevBrain Health Imaging Centre, Centre for Addiction and Mental Health and University of Toronto, Toronto, Canada.
Guy BormansLaboratory for Radiopharmaceutical Research, Department of Pharmacy and Pharmacologic Sciences, KU Leuven, Leuven, Belgium; guy.bormans@kuleuven.be.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Heat shock protein 90 (Hsp90) is essential for maintaining cellular proteostasis and may play an important role in the development of neurodegenerative proteinopathies. Therefore, we aimed to develop an Hsp90-specific PET brain tracer to quantify Hsp90 expression in the brain in vivo in order to explore its potential as a biomarker for neurodegenerative disease characterization and to support Hsp90-targeted drug development.

Indexed as

AgingBrainHSP90 Heat-Shock ProteinsNeurodegenerative DiseasesAgedAlzheimer DiseaseAnimalsCarbon RadioisotopesFemaleHumansMaleMiceMiddle AgedParkinson DiseasePositron-Emission TomographyRatsCarbon-11Carbon RadioisotopesHSP90 Heat-Shock ProteinsbrainHsp90neurodegenerationPET

Identifiers

PMID40306968
PMCPMC12175989

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.