Evidence map›Paper›PMID 40306854›Full record

ArticleJACC. Basic to translational science2025

Shear-Thinning Hydrogel for Delayed Delivery of a Small Molecule Metalloproteinase Inhibitor Attenuates Myocardial Infarction Remodeling.

Joshua E Mealy, William M Torres, Lisa A Freeburg, Shayne C Barlow, Alison A Whalen, Chima V Maduka, Tarek M Shazly, Jason A Burdick, Francis G Spinale

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JACC. Basic to translational science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. [Advances in hydrogel drug delivery systems for myocardial infarction treatment].Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2025
    Review
  3. Delaying Drug Release: A Time Capsule for the Heart.JACC. Basic to translational science · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Joshua E MealyDepartment of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
William M TorresCollege of Engineering and Computing, University of South Carolina, Columbia, South Carolina, USA; Cardiovascular Translational Research Center, University of South Carolina School of Medicine, Columbia, South Carolina, USA.
Lisa A FreeburgCardiovascular Translational Research Center, University of South Carolina School of Medicine, Columbia, South Carolina, USA.
Shayne C BarlowCardiovascular Translational Research Center, University of South Carolina School of Medicine, Columbia, South Carolina, USA.
Alison A WhalenCardiovascular Translational Research Center, University of South Carolina School of Medicine, Columbia, South Carolina, USA.
Chima V MadukaBioFrontiers Institute and Department of Chemical and Biological Engineering, University of Colorado-Boulder, Boulder, Colorado, USA.
Tarek M ShazlyCollege of Engineering and Computing, University of South Carolina, Columbia, South Carolina, USA.
Jason A BurdickDepartment of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania, USA; BioFrontiers Institute and Department of Chemical and Biological Engineering, University of Colorado-Boulder, Boulder, Colorado, USA.
Francis G SpinaleCollege of Engineering and Computing, University of South Carolina, Columbia, South Carolina, USA; Cardiovascular Translational Research Center, University of South Carolina School of Medicine, Columbia, South Carolina, USA; Columbia VA Health Care Center, Columbia, South Carolina, USA. Electronic address: cvctrc@uscmed.sc.edu.

Funding

Fibroblast targeting for myocardial repairR01HL167994 · NHLBI · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI FRANCIS G SPINALE · 2023 to 2026
$2.6M
Therapeutic Targeting of Tissue Inhibitor-4 in Hypertrophy and FailureR01HL130972 · NHLBI · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI SPINALE, FRANCIS G · 2016 to 2019
$1.9M
BLRD VA I01 BX000168BLRD VA I01 BX005320NHLBI NIH HHS R01 HL130972NHLBI NIH HHS R01 HL167994
6 · The paper itself

Abstract

Strategic delivery of hydrogels to the newly formed myocardial infarction (MI) is an area of active investigation and offers high target specificity for releasing a small molecule therapeutic payload. This study examined the effects of delayed post-MI delivery (pigs, 3 days post-MI) of a shear-thinning hydrogel which encapsulated and released a small molecule matrix metalloproteinase inhibitor. The results demonstrated the feasibility and efficacy of targeted delivery of a shear-thinning injectable hydrogel containing a small molecule matrix metalloproteinase inhibitor to attenuate post-MI remodeling.

Indexed as

extracellular remodellingmatrix metalloproteinaseventricular function and failure

Identifiers

PMID40306854
PMCPMC12134564

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.