Evidence map›Paper›PMID 40306833›Full record

ReviewThe Lancet. Haematology2025

Management of iron deficiency in children, adults, and pregnant individuals: evidence-based and expert consensus recommendations.

Ashley E Benson, Jamie O Lo, Maureen O Achebe, Jorgeane S Aslan, Michael Auerbach, Bethany T Samuelson Bannow, Marie J Boller, Thomas G Deloughery, Jacquelin Dingman, Layla Van Doren and 26 more

Abstract readReviewConsensus Statement
PubMed Full text at PMC Publisher
In one paragraph

Review in The Lancet. Haematology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed.

  1. Trial
  2. Implementation strategies: bridging obstetrics and long-term care.American journal of obstetrics & gynecology MFM · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

36 authors.

Ashley E BensonDivision of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Oregon Health & Science University, Portland, OR, USA.
Jamie O LoDivision of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Oregon Health & Science University, Portland, OR, USA; Department of Urology, Oregon Health & Science University, Portland, OR, USA. Electronic address: loj@ohsu.edu.
Maureen O AchebeDivision of Hematology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Jorgeane S AslanDivision of Hematology and Medical Oncology, Knight Cancer Institute, Oregon Health & Science University, Portland, OR, USA.
Michael AuerbachDepartment of Medicine, Georgetown University School of Medicine, Washington, DC, USA.
Bethany T Samuelson BannowDivision of Hematology and Medical Oncology, Knight Cancer Institute, Oregon Health & Science University, Portland, OR, USA.
Marie J BollerDivision of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Oregon Health & Science University, Portland, OR, USA.
Thomas G DelougheryDivision of Hematology and Medical Oncology, Knight Cancer Institute, Oregon Health & Science University, Portland, OR, USA.
Jacquelin DingmanKnight Cancer Institute, Oregon Health & Science University, Portland, OR, USA.
Layla Van DorenSection of Hematology, Department of Medicine, Yale School of Medicine, New Haven, CT, USA.
Geolani W DyDepartment of Urology, Oregon Health & Science University, Portland, OR, USA.
Patricia A FordAbramson Cancer Center, Pennsylvania Hospital of the University of Pennsylvania, Philadelphia, PA, USA.
Jason A FreedDivision of Hematology and Hematologic Malignancies, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Michael K GeorgieffDivision of Neonatology, Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA.
Kristina M HaleyDivision of Pediatric Hematology and Oncology, Department of Pediatrics, Oregon Health & Science University, Portland, OR, USA.
Chloe I HanDivision of Pediatric Critical Care, Department of Pediatrics, Oregon Health & Science University, Portland, OR, USA.
Adam K LewkowitzDivision of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Brown University Warren Alpert Medical School, Providence, RI, USA.
Kylee L MartensDivision of Hematology and Medical Oncology, Knight Cancer Institute, Oregon Health & Science University, Portland, OR, USA.
Robert T MeansDepartments of Internal Medicine, Medical Education, and Pathology, James H Quillen College of Medicine, East Tennessee State University, Johnson City, TN, USA.
Elizabeta NemethDepartment of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
Sven R OlsonKnight Cancer Institute, Oregon Health & Science University, Portland, OR, USA.
Jacquelyn M PowersDivision of Hematology/Oncology, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA.
Kristin C PrewittDivision of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Oregon Health & Science University, Portland, OR, USA.
Toby RichardsInstitute of Clinical Trials and Methodology, University College London, London, UK.
Don C RockeyMedical University of South Carolina Digestive Disease Research Center, Medical University of South Carolina, Charleston, SC, USA.
Eric J RoelandKnight Cancer Institute, Oregon Health & Science University, Portland, OR, USA.
Kimberly S RyanDivision of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Oregon Health & Science University, Portland, OR, USA.
Hanny Al-SamkariMassachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Michelle SholzbergDepartments of Medicine, and Laboratory Medicine & Pathobiology, St. Michael's Hospital, Li Ka Shing Knowledge Institute, University of Toronto, Toronto, ON, Canada.
Methodius G TuuliDivision of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Brown University Warren Alpert Medical School, Providence, RI, USA.
Angela C WeyandDepartment of Pediatrics, University of Michigan Medical School, Ann Arbor, MI, USA.
Michelle P ZellerMichael G DeGroote Centre for Transfusion Research, Department of Medicine, McMaster University, Hamilton, ON Canada; Canadian Blood Services, Hamilton, ON, Canada.
Annette M TottenPacific Northwest Evidence-based Practice Center, Oregon Health & Science University, Portland, OR, USA.
Ilya IvlevPacific Northwest Evidence-based Practice Center, Oregon Health & Science University, Portland, OR, USA.
Joseph J ShatzelDivision of Hematology and Medical Oncology, Knight Cancer Institute, Oregon Health & Science University, Portland, OR, USA.
Iron Consortium at Oregon Health & Science University

Funding

Scholars in Women's Health Research Across the LifespanK12HD043488 · NICHD · OREGON HEALTH & SCIENCE UNIVERSITY · PI MYATT, LESLIE · 2002 to 2023
$10.4M
Evaluating the Safety and Efficacy of Targeting the Contact Pathway to Prevent Device Associated Thrombosis.R01HL151367 · NHLBI · OREGON HEALTH & SCIENCE UNIVERSITY · PI SHATZEL, JOSEPH JAMES · 2020 to 2024
$1.5M
NHLBI NIH HHS R01 HL151367NICHD NIH HHS K12 HD043488
6 · The paper itself

Abstract

Iron deficiency is the most common micronutrient deficiency worldwide. Oral iron is often recommended as first-line treatment, but there is no consensus on the optimal formulation, dosing strategy, or which patients should be treated preferentially with intravenous iron. To address these challenges, the Iron Consortium at Oregon Health & Science University (OHSU) convened an international panel of 26 experts in haematology, primary care, paediatrics, obstetrics, gastroenterology, cancer, and patient advocacy among its members. This panel was supplemented by insights from a four-person patient focus group to develop current recommendations using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) methodology. The panel developed clinically relevant questions in five priority topic areas, a systematic literature search was performed, and studies meeting a priori criteria were included to generate evidence tables for recommendation development. Evidence-based and expert opinion-based recommendations were made through a structured anonymous consensus voting process at an in-person meeting in Portland, OR, USA, hosted by OHSU on Feb 16-17, 2024. The expert panel made seven evidence-based recommendations for three demographic groups with iron deficiency: non-pregnant adults, pregnant individuals, and infants, children, and adolescents. Expert opinions supported the recommendations on 21 aspects of care for which there is insufficient evidence. This Review provides evidence-based recommendations and expert consensus on the diagnosis, treatment, and management of iron deficiency, detailing best practices for oral and intravenous iron repletion across diverse patient populations.

Indexed as

Anemia, Iron-DeficiencyIronIron DeficienciesAdolescentAdultChildDisease ManagementEvidence-Based MedicineFemaleHumansInfantPregnancyIron

Identifiers

PMID40306833
PMCPMC13618744

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.