Evidence map›Paper›PMID 40306316›Full record

ArticleNature2025

A DNA-gated molecular guard controls bacterial Hailong anti-phage defence.

Joel M J Tan, Sarah Melamed, Joshua C Cofsky, Deepsing Syangtan, Samuel J Hobbs, Josefina Del Mármol, Marco Jost, Andrew C Kruse, Rotem Sorek, Philip J Kranzusch

Abstract read
In one paragraph

Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. How bacterial immune systems sense phage infection.Nature reviews. Microbiology · 2026
    Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Cryo-EM reveals ArnA contamination during purification of a ciliary protein complex.Acta crystallographica. Section D, Structural biology · 2026
    Article
  9. Article
  10. Article
  11. [Research on Bacteriophage Resistance: Coevolutionary Arms Race Between Bacteria and Phages Drives Novel Antibacterial Therapies].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2026
    Review
  12. Review
  13. Advances in phage therapy forFrontiers in microbiology · 2026
    Review
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Joel M J TanDepartment of Microbiology, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-6051-3786
Sarah MelamedDepartment of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel.
Joshua C CofskyDepartment of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.
Deepsing SyangtanDepartment of Microbiology, Harvard Medical School, Boston, MA, USA.
Samuel J HobbsDepartment of Microbiology, Harvard Medical School, Boston, MA, USA.
Josefina Del MármolDepartment of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.ORCID 0000-0003-2715-0482
Marco JostDepartment of Microbiology, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-1369-4908
Andrew C KruseDepartment of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-1467-1222
Rotem SorekDepartment of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel.ORCID 0000-0002-3872-4982
Philip J KranzuschDepartment of Microbiology, Harvard Medical School, Boston, MA, USA. philip_kranzusch@dfci.harvard.edu.ORCID 0000-0002-4943-733X

Funding

X-ray Scattering Technology CoreP30GM133893 · NIGMS · BROOKHAVEN SCIENCE ASSOC-BROOKHAVEN LAB · PI Lin Yang · 2019 to 2026
$38.6M
Project 3: Defining and defeating the mechanisms of outer membrane biogenesis in Gram-negative bacteriaU19AI158028 · NIAID · HARVARD MEDICAL SCHOOL · PI WALKER, SUZANNE · 2022 to 2025
$10.1M
Capturing, quantifying, and understanding combinatorial effects in small molecule signalingDP2GM154152 · NIGMS · HARVARD MEDICAL SCHOOL · PI Marco Jost · 2023 to 2026
$2.5M
Discovery of cGAS-like signaling enzymes in innate immunity and diseaseDP2GM146250 · NIGMS · DANA-FARBER CANCER INST · PI KRANZUSCH, PHILIP J · 2021 to 2024
$2.5M
Elucidating the structural determinants of odor specificity in insect olfactory receptorsR00DC019401 · NIDCD · HARVARD MEDICAL SCHOOL · PI DEL MARMOL, JOSEFINA INÉS · 2022 to 2024
$747k
NIAID NIH HHS U19 AI158028NIDCD NIH HHS R00 DC019401NIGMS NIH HHS DP2 GM146250NIGMS NIH HHS DP2 GM154152NIGMS NIH HHS P30 GM133893
6 · The paper itself

Abstract

Animal and bacterial cells use nucleotidyltransferase (NTase) enzymes to respond to viral infection and control major forms of immune signalling including cGAS-STING innate immunity and CBASS anti-phage defence

Indexed as

Bacterial ProteinsBacteriophagesDNA, BacterialNucleotidyltransferasesCryoelectron MicroscopyCrystallography, X-RayDNA, Single-StrandedDNA, ViralModels, MolecularProtein DomainsVirus ReplicationBacterial ProteinsDNA, BacterialDNA, Single-StrandedDNA, ViralNucleotidyltransferases

Identifiers

PMID40306316
PMCPMC12360457

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.