Evidence map›Paper›PMID 40306279›Full record

ArticleCell2025

Selective requirement of glycosphingolipid synthesis for natural killer and cytotoxic T cells.

Tasha A Morrison, Jaelyn Vigee, Kevin A Tovar, Taylor A Talley, Adriana M Mujal, Mari Kono, Rachael Philips, Hiroyuki Nagashima, Stephen R Brooks, Hannah Dada and 14 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Review
  3. A Microbial Lipid-ATP Synthase Axis Fuels NK Cell Antitumor Activity.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  4. The EGR1/ZFP36 axis governs glycosphingolipid metabolic reprogramming in monocyte-derived macrophages in guillain-barré syndrome.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026
    Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Review
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Tasha A MorrisonLymphocyte Cell Biology Section, Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health (NIH), Bethesda, MD, USA; Lymphocyte Signaling Unit, Molecular Immunology and Inflammation Branch, NIAMS, NIH, Bethesda, MD, USA. Electronic address: tasha.morrison@nih.gov.
Jaelyn VigeeLymphocyte Signaling Unit, Molecular Immunology and Inflammation Branch, NIAMS, NIH, Bethesda, MD, USA.
Kevin A TovarLymphocyte Signaling Unit, Molecular Immunology and Inflammation Branch, NIAMS, NIH, Bethesda, MD, USA.
Taylor A TalleyLymphocyte Signaling Unit, Molecular Immunology and Inflammation Branch, NIAMS, NIH, Bethesda, MD, USA.
Adriana M MujalImmunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Mari KonoGenetics of Development and Disease Section, Genetics and Biochemistry Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD, USA.
Rachael PhilipsLymphocyte Cell Biology Section, Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health (NIH), Bethesda, MD, USA.
Hiroyuki NagashimaLymphocyte Cell Biology Section, Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health (NIH), Bethesda, MD, USA.
Stephen R BrooksBiodata Mining and Discovery Section, NIAMS, NIH, Bethesda, MD, USA.
Hannah DadaLymphocyte Cell Biology Section, Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health (NIH), Bethesda, MD, USA.
Isaiah RozichLymphocyte Cell Biology Section, Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health (NIH), Bethesda, MD, USA.
Kelly HudspethLymphocyte Cell Biology Section, Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health (NIH), Bethesda, MD, USA.
Colleen M LauDepartment of Microbiology and Immunology, Cornell University College of Veterinary Medicine, Ithaca, NY, USA.
Chen YaoDepartment of Immunology, University of Texas Southwestern Medical School, Dallas, TX, USA.
Giuseppe SciumèDepartment of Molecular Medicine, Laboratory affiliated to Istituto Pasteur Italia - Fondazione Cenci Bolognetti, "Sapienza" University of Rome, Rome, Italy.
Hong-Wei SunBiodata Mining and Discovery Section, NIAMS, NIH, Bethesda, MD, USA.
Juan S BonifacinoDivision of Neurosciences and Cellular Structure, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Bethesda, MD, USA.
Yuka KannoLymphocyte Cell Biology Section, Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health (NIH), Bethesda, MD, USA.
Michael L DustinKennedy Institute of Rheumatology, University of Oxford, Oxford, UK.
Davide RandazzoLight Imaging Section, NIAMS, NIH, Bethesda, MD, USA.
Richard L ProiaGenetics of Development and Disease Section, Genetics and Biochemistry Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD, USA.
Joseph C SunImmunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Han-Yu ShihNeuro-immune Regulome Unit, National Eye Institute, NIH, Bethesda, MD, USA.
John J O'SheaLymphocyte Cell Biology Section, Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health (NIH), Bethesda, MD, USA. Electronic address: john.oshea@nih.gov.

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4M
Lymphocyte signaling and immune cell responseZIAAR041230 · NIAMS · NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES · PI MORRISON, TASHA · 2022 to 2025
$3.0M
Harnessing Stem-Like CD8 T Cells for Immunotherapies to Eradicate HIV ReservoirsDP2AI154450 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI YAO, CHEN · 2021 to 2025
$2.5M
Intramural NIH HHS Z99 AR999999Intramural NIH HHS ZIA AR041230NCI NIH HHS P30 CA008748NIAID NIH HHS DP2 AI154450
6 · The paper itself

Abstract

Cell identity genes that exhibit complex regulation are marked by super-enhancer (SE) architecture. Assessment of SEs in natural killer (NK) cells identified Ugcg, encoding the enzyme responsible for glycosphingolipid (GSL) synthesis. Conditional deletion of Ugcg in early hematopoiesis abrogated NK cell generation while sparing other lineages. Pharmacological inhibition of UGCG disrupted cytotoxic granules and cytotoxicity, reduced expansion after viral infection, and promoted apoptosis. B4galt5 transcribes an enzyme downstream of UGCG and possesses SE structure. Addition of its product, lactosylceramide (LacCer), reversed apoptosis due to UGCG inhibition. By contrast, complex GSLs, such as asialo-GM1, were not required for NK cell viability and granule integrity. Ugcg and B4galt5 were upregulated in CD8

Indexed as

GlycosphingolipidsKiller Cells, NaturalT-Lymphocytes, CytotoxicAnimalsApoptosisCD8-Positive T-LymphocytesGalactosyltransferasesMiceMice, Inbred C57BLGalactosyltransferasesGlycosphingolipidsUDP-galactose-lactosylceramide alpha 1-4-galactosyltransferaseB4galt5CD8(+) T cellscytotoxic granulesglycosphingolipidsimmunometabolismlactosylceramidelymphocytesnatural killer cellssuper-enhancersUgcg

Identifiers

PMID40306279
PMCPMC12204804

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.