Evidence map›Paper›PMID 40306226›Full record

ArticleSleep medicine2025

Exploring nightly variability and clinical influences on sleep measures: insights from a digital brain health platform.

Huitong Ding, Sanskruti Madan, Edward Searls, Matthew McNulty, Spencer Low, Zexu Li, Kristi Ho, Salman Rahman, Akwaugo Igwe, Zachary Popp and 8 more

Abstract read
In one paragraph

Article in Sleep medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
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  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Huitong DingDepartment of Anatomy and Neurobiology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA; The Framingham Heart Study, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.
Sanskruti MadanDepartment of Anatomy and Neurobiology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.
Edward SearlsDepartment of Anatomy and Neurobiology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.
Matthew McNultyDepartment of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Spencer LowDepartment of Anatomy and Neurobiology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.
Zexu LiDepartment of Anatomy and Neurobiology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.
Kristi HoDepartment of Anatomy and Neurobiology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.
Salman RahmanDepartment of Anatomy and Neurobiology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.
Akwaugo IgweDepartment of Anatomy and Neurobiology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.
Zachary PoppDepartment of Anatomy and Neurobiology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.
Phillip H HwangDepartment of Anatomy and Neurobiology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA; The Framingham Heart Study, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA; Department of Epidemiology, Boston University School of Public Health, Boston, MA, USA.
Ileana De Anda-DuranSchool of Public Health and Tropical Medicine, Tulane University, New Orleans, LA, USA.
Vijaya B KolachalamaDepartment of Medicine, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA; Department of Computer Science and Faculty of Computing & Data Sciences, Boston University, Boston, MA, USA.
Jesse MezDepartment of Anatomy and Neurobiology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA; Boston University Alzheimer's Disease Research Center, Boston University CTE Center, Departments of Neurology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA; Department of Neurology, Boston Medical Center, USA.
Michael L AloscoDepartment of Anatomy and Neurobiology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA; Boston University Alzheimer's Disease Research Center, Boston University CTE Center, Departments of Neurology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA; Department of Neurology, Boston Medical Center, USA.
Robert J ThomasDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Rhoda AuDepartment of Anatomy and Neurobiology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA; The Framingham Heart Study, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA; Department of Epidemiology, Boston University School of Public Health, Boston, MA, USA; Department of Medicine, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA; Boston University Alzheimer's Disease Research Center, Boston University CTE Center, Departments of Neurology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA; Slone Epidemiology Center, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.
Honghuang LinDepartment of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA. Electronic address: honghuang.lin@umassmed.edu.

Funding

TBDU19AG068753 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI Thor Stein · 2020 to 2026
$42.4M
Neuropathology CoreP30AG013846 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI KOWALL, NEIL W. · 1996 to 2020
$29.1M
PRECURSORS OF STROKE INCIDENCE AND PROGNOSISR01NS017950 · NINDS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Hugo Javier Aparicio, Jose Rafael Romero · 1985 to 2026
$22.9M
EPIDEMIOLOGY OF DEMENTIA IN THE FRAMINGHAM STUDYR01AG008122 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI AU, RHODA, SESHADRI, SUDHA · 1989 to 2015
$14.4M
MRI, Genetics &Cognitive Precursors of AD &DementiaR01AG016495 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI AU, RHODA · 1999 to 2016
$12.5M
Social and behavioral determinants of health and Alzheimer’s Disease: Cohort study of the US military veteran populationR01AG080670 · NIA · UNIVERSITY OF MASSACHUSETTS LOWELL · PI HONG YU · 2023 to 2026
$4.5M
Re-visiting Methods for MCI Diagnosis to Improve Biomarker and Trial FindingsR01AG049810 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BONDI, MARK W, EDLAND, STEVEN DYAL · 2016 to 2020
$3.7M
Epigenetic changes in synaptic and inflammatory genes involved in the age-dependent development of Alzheimer's disease pathologies andcognitive declineRF1AG054156 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI AU, RHODA, RYU, HOON · 2016 to 2018
$3.4M
Assessing Alzheimer disease risk and heterogeneity using multimodal machine learning approachesU01AG068221 · NIA · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI DESTEFANO, ANITA L, LIN, HONGHUANG · 2021 to 2024
$2.5M
Digital Cognitive Assessment of Preclinical Alzheimer's Disease and Related DementiasR01AG083735 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI Rhoda Au, Vijaya B. Kolachalama · 2024 to 2026
$2.4M
Cognitive Heterogeneity in those with high Alzheimer's Disease RiskRF1AG062109 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI AU, RHODA · 2020 to 2021
$1.8M
Cognitive heterogeneity in those with high Alzheimer's Disease RiskR01AG062109 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI Rhoda Au, Vijaya B. Kolachalama · 2025 to 2026
$1.6M
NHLBI NIH HHS N01 HC025195NHLBI NIH HHS R21 HL175584NIA NIH HHS P30 AG013846NIA NIH HHS R01 AG008122NIA NIH HHS R01 AG016495NIA NIH HHS R01 AG049810NIA NIH HHS R01 AG062109NIA NIH HHS R01 AG080670NIA NIH HHS R01 AG083735NIA NIH HHS R56 AG062109NIA NIH HHS RF1 AG054156NIA NIH HHS RF1 AG062109NIA NIH HHS U01 AG068221NIA NIH HHS U19 AG068753NINDS NIH HHS R01 NS017950
6 · The paper itself

Abstract

backgroundDigital technology offers a convenient way to continuously monitor sleep and assess night-to-night variability, particularly in aging populations where traditional self-reported sleep assessments may be limited.

aimsThis study aimed to investigate nightly variability in sleep measures obtained via a ring oximeter sensor in older adults and to explore the influence of demographic and cognitive factors on the stability of these metrics.

methodsThe study included 62 participants (mean age 74, 67.7 % women, 90.3 % White) from the Boston University Alzheimer's Disease Research Center (BU ADRC) cohort. Each participant wore a SleepImage Ring for at least three consecutive nights. Thirty-four continuous sleep measures, such as mean SpO2 and apnea-hypopnea index within unstable sleep, were analyzed. Night-to-night variability was assessed using intraclass correlation coefficients (ICC) based on a two-way random-effects model. Subgroup analyses examined variability by sex, age, and cognitive status. Group-level changes were assessed using one-way repeated measures ANOVA.

resultsSeven sleep measures demonstrated high stability across nights (ICC: 0.70-0.88), with average heart rate being the most stable, followed by mean SpO

conclusionAt least three nights of monitoring are required for reliable estimates of key sleep metrics. Expanding studies with larger samples and extended monitoring periods could further elucidate sleep variability as a potential non-invasive marker for general health.

Indexed as

Digital TechnologyPolysomnographySleepAgedAged, 80 and overFemaleHeart RateHumansMaleMiddle AgedOximetryCognitive impairmentSleep measuresVariability

Identifiers

PMID40306226
PMCPMC12086039

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.