Evidence map›Paper›PMID 40305985›Full record

ReviewEBioMedicine2025

The potential of large language models to advance precision oncology.

Shufan Liang, Jiangjiang Zhang, Xingting Liu, Yinkui Huang, Jun Shao, Xiaohong Liu, Weimin Li, Guangyu Wang, Chengdi Wang

Abstract readReview
In one paragraph

Review in EBioMedicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Article
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  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. ChatGPT in precision medicine.APL bioengineering · 2026
    Review
  10. Review
  11. Review
  12. Review
  13. Review
  14. Review
  15. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Shufan LiangDepartment of Pulmonary and Critical Care Medicine, State Key Laboratory of Respiratory Health and Multimorbidity, Targeted Tracer Research and Development Laboratory, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, West China School of Medicine, Sichuan University, Chengdu, China.
Jiangjiang ZhangState Key Laboratory of Networking and Switching Technology, Beijing University of Posts and Telecommunications, Beijing, China.
Xingting LiuDepartment of Pulmonary and Critical Care Medicine, State Key Laboratory of Respiratory Health and Multimorbidity, Targeted Tracer Research and Development Laboratory, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, West China School of Medicine, Sichuan University, Chengdu, China.
Yinkui HuangState Key Laboratory of Networking and Switching Technology, Beijing University of Posts and Telecommunications, Beijing, China.
Jun ShaoDepartment of Pulmonary and Critical Care Medicine, State Key Laboratory of Respiratory Health and Multimorbidity, Targeted Tracer Research and Development Laboratory, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, West China School of Medicine, Sichuan University, Chengdu, China.
Xiaohong LiuState Key Laboratory of Networking and Switching Technology, Beijing University of Posts and Telecommunications, Beijing, China; UCL Cancer Institute, University College London, London WC1E 6BT, UK.
Weimin LiDepartment of Pulmonary and Critical Care Medicine, State Key Laboratory of Respiratory Health and Multimorbidity, Targeted Tracer Research and Development Laboratory, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, West China School of Medicine, Sichuan University, Chengdu, China; Frontiers Medical Center, Tianfu Jincheng Laboratory, Chengdu, China. Electronic address: weimi003@scu.edu.cn.
Guangyu WangState Key Laboratory of Networking and Switching Technology, Beijing University of Posts and Telecommunications, Beijing, China. Electronic address: guangyu.wang24@gmail.com.
Chengdi WangDepartment of Pulmonary and Critical Care Medicine, State Key Laboratory of Respiratory Health and Multimorbidity, Targeted Tracer Research and Development Laboratory, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, West China School of Medicine, Sichuan University, Chengdu, China; Frontiers Medical Center, Tianfu Jincheng Laboratory, Chengdu, China. Electronic address: chengdi_wang@scu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

With the rapid development of artificial intelligence (AI) within medicine, the emergence of large language models (LLMs) has gradually reached the forefront of clinical research. In oncology, by mining the underlying connection between a text or image input and the desired output, LLMs demonstrate great potential for managing tumours. In this review, we provide a brief description of the development of LLMs, followed by model construction strategies and general medical functions. We then elaborate on the role of LLMs in cancer screening and diagnosis, metastasis identification, tumour staging, treatment recommendation, and documentation processing tasks by decoding various types of clinical data. Moreover, the current barriers faced by LLMs, such as hallucinations, ethical problems, limited application, and so on, are outlined along with corresponding solutions, where the further purpose is to inspire improvement and innovation in this field with respect to harnessing LLMs for advancing precision oncology.

Indexed as

Medical OncologyNeoplasmsPrecision MedicineArtificial IntelligenceHumansLarge Language ModelsArtificial intelligenceDiagnosisLarge language modelOncologyTreatment

Identifiers

PMID40305985
PMCPMC12083916

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.