Evidence map›Paper›PMID 40305883›Full record

ArticleRedox biology2025

Knockout of the sulfide: quinone oxidoreductase SQR reduces growth of HCT116 tumor xenograft.

Ting Lu, Qingda Wang, Yuping Xin, Xiaohua Wu, Yang Wang, Yongzhen Xia, Luying Xun, Huaiwei Liu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Redox biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ting LuSchool of Health and Life Sciences, University of Health and Rehabilitation Sciences Qingdao Hospital (Qingdao Municipal Hospital), University of Health and Rehabilitation Sciences, Qingdao, 266071, People's Republic of China.
Qingda WangState Key Laboratory of Microbial Technology, Shandong University, Qingdao, 266200, People's Republic of China.
Yuping XinState Key Laboratory of Microbial Technology, Shandong University, Qingdao, 266200, People's Republic of China.
Xiaohua WuState Key Laboratory of Microbial Technology, Shandong University, Qingdao, 266200, People's Republic of China.
Yang WangOrigin Biotechnology Private Limited, 2 Venture Drive, 608526, Singapore.
Yongzhen XiaState Key Laboratory of Microbial Technology, Shandong University, Qingdao, 266200, People's Republic of China.
Luying XunState Key Laboratory of Microbial Technology, Shandong University, Qingdao, 266200, People's Republic of China; School of Molecular Biosciences, Washington State University, Pullman, WA, 991647520, USA.
Huaiwei LiuState Key Laboratory of Microbial Technology, Shandong University, Qingdao, 266200, People's Republic of China. Electronic address: liuhuaiwei@sdu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Colorectal cancer (CRC) exhibits significant diversity and heterogeneity, posing a requirement for novel therapeutic targets. Polysulfides are associated with CRC progression and immune evasion, but the underlying mechanisms are not fully understood. Sulfide: quinone oxidoreductase (SQR), a mitochondrial flavoprotein, catalyzes hydrogen sulfide (H

Indexed as

Colorectal NeoplasmsQuinone ReductasesAnimalsApoptosisCell ProliferationFructose-Bisphosphate AldolaseGene Knockout TechniquesGlycolysisHCT116 CellsHumansMiceMitochondriaXenograft Model Antitumor AssaysFructose-Bisphosphate AldolaseQuinone Reductasessulfide quinone reductaseALDOAColorectal cancerHCT116PolysulfidesSQRTumor xenograft

Identifiers

PMID40305883
PMCPMC12433914

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.