Evidence map›Paper›PMID 40305785›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025

Dual Role of CRABP2 in Colorectal Cancer: Oncogenesis via Nuclear RB1 and Cytoplasmic AFG3L2/SLC25A39 Axis, While Limiting Liver Metastasis through Cytoplasmic AFG3L2/PINK1/Parkin-Mediated Mitophagy.

Chuanxin Tian, Sheng Yang, Chuan Zhang, Renzhong Zhu, Chen Chen, Xiaowei Wang, Dongsheng Zhang, Qingyang Sun, Hengjie Xu, Hongxu Nie and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Chuanxin TianDepartment of General Surgery, Colorectal Institute of Nanjing Medical University, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.
Sheng YangDepartment of General Surgery, Colorectal Institute of Nanjing Medical University, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.
Chuan ZhangDepartment of General Surgery, Colorectal Institute of Nanjing Medical University, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.
Renzhong ZhuInstitute of Translational Medicine, Medical College, Yangzhou University, No.136 Jiangyang Road, Yangzhou, 210029, China.
Chen ChenDepartment of General Surgery, Colorectal Institute of Nanjing Medical University, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.
Xiaowei WangDepartment of General Surgery, Colorectal Institute of Nanjing Medical University, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.
Dongsheng ZhangDepartment of General Surgery, Colorectal Institute of Nanjing Medical University, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.
Qingyang SunDepartment of General Surgery, Colorectal Institute of Nanjing Medical University, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.
Hengjie XuDepartment of General Surgery, Colorectal Institute of Nanjing Medical University, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.
Hongxu NieDepartment of General Surgery, Colorectal Institute of Nanjing Medical University, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.
Yue ZhangDepartment of General Surgery, Colorectal Institute of Nanjing Medical University, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.
Dongjian JiDepartment of General Surgery, Colorectal Institute of Nanjing Medical University, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.
Junwei TangDepartment of General Surgery, Colorectal Institute of Nanjing Medical University, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.
Kangpeng JinDepartment of General Surgery, Colorectal Institute of Nanjing Medical University, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.
Yueming SunDepartment of General Surgery, Colorectal Institute of Nanjing Medical University, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.

Funding

Basic Research Program of Jiangsu Province BK20221415Basic Research Program of Jiangsu Province TJ-2023-051Jiangsu Province Capability Improvement Project through Science, Technology, and Education BK20221415Jiangsu Provincial Association of Science and Technology, Youth Science and Technology Talent Recruitment Project ZDXK202222The National Natural Science Foundation 82100617The National Natural Science Foundation 82203768The National Natural Science Foundation 82273406The National Natural Science Foundation 82304221The National Natural Science Foundation 82473042The National Natural Science Foundation 82473049
6 · The paper itself

Abstract

Colorectal cancer (CRC) progression and metastasis involve numerous regulatory factors. Among these, cellular retinoic acid-binding protein 2 (CRABP2) has been implicated as both a tumor activator and suppressor. Here, it is aimed to clarify the role of CRABP2 in CRC growth and metastasis and explore the underlying molecular mechanisms mediating its cellular functions. Using both in vitro and in vivo models, including a colonocyte-specific CRABP2 conditional knockout mouse model (Crabp2

Indexed as

Colorectal NeoplasmsLiver NeoplasmsMitophagyRetinoblastoma Binding ProteinsUbiquitin-Protein LigasesAnimalsCarcinogenesisCell Line, TumorCell ProliferationCytoplasmHumansMiceMice, Inbred BALB CMice, KnockoutMice, NudeProtein Kinasesparkin proteinProtein KinasesPTEN-Induced Putative KinaseRetinoblastoma Binding ProteinsUbiquitin-Protein LigasesAFG3L2cellular retinoic acid–binding proteinscolorectal cancerCRABP2liver metastasismitophagyPINK1RB1

Identifiers

PMID40305785
PMCPMC12199395

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.