ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025
The GhWL1-GhH1-GhGA2OX1 Transcriptional Module Regulates Cotton Leaf Morphology.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Genetic Mapping and Functional Characterisation of GhCUP Regulating Leaf Curling in Cotton.Plant biotechnology journal · 2026Article
- The GhWL1-GhH1-GhGA2OX1 Transcriptional Module Regulates Cotton Leaf Morphology.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- A single-nucleotide mutation of G301A inFrontiers in plant science · 2025Article
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Authors and funding
13 authors.
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Abstract
Leaf morphology critically influences photosynthetic efficiency, directly affecting crop yield and quality. In this study, a T-DNA insertion mutant (wl-D), characterized by a wrinkled-leaf phenotype, is identified. Genetic analysis reveals that this phenotype is governed by a single dominant gene, WRINKLED-LEAF 1 (GhWL1), which is highly expressed in wl-D compared to the wild type (WT). Overexpression of GhWL1 in WT caused curling at leaf edges, while suppression of GhWL1 in wl-D restored normal leaf morphology, validating its functional role. Further analysis demonstrated that GhWL1 interacts with GhH1, a protein with a KNOX1 structural domain, to regulate leaf development. Overexpression of GhH1 in WT results in a leaf shrinkage phenotype similar to wl-D, whereas suppressing GhH1 in wl-D restored normal leaf morphology, indicating that GhH1 acts downstream of GhWL1. The GhWL1-GhH1 complex directly binds to the promoter of GhGA2OX1 (gibberellin 2-beta-dioxygenase 1), positively regulating its expression. Overexpression of GhGA2OX1 in WT mimicked the leaf shrinkage phenotype observed in plants overexpressing GhH1. These findings establish the GhWL1-GhH1-GhGA2OX1 module as a critical pathway in regulating leaf development, offering valuable insights into the genetic and hormonal networks controlling leaf morphological diversity.
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