Evidence map›Paper›PMID 40305665›Full record

ArticleAmerican journal of respiratory cell and molecular biology2025

Construction of an Indole-induced Transgenic System and Its Therapeutic Effects on Allergic Rhinitis.

Guangyao Li, Shengju Li, Fangzhou Ye, Keguang Chen, Hongmeng Yu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of respiratory cell and molecular biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Switching On Gene Therapy for Allergic Rhinitis: The AAVITS Approach.American journal of respiratory cell and molecular biology · 2025
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Guangyao LiDepartment of Otolaryngology, Eye & ENT Hospital, Fudan University, Shanghai, People's Republic of China.
Shengju LiDepartment of Otolaryngology, Eye & ENT Hospital, Fudan University, Shanghai, People's Republic of China.
Fangzhou YeDepartment of Otolaryngology, Eye & ENT Hospital, Fudan University, Shanghai, People's Republic of China.
Keguang ChenDepartment of Otorhinolaryngology - Head and Neck Surgery, Shanghai Zhongshan Hospital Affiliated to Fudan University, Shanghai, People's Republic of China; and.
Hongmeng YuDepartment of Otolaryngology, Eye & ENT Hospital, Fudan University, Shanghai, People's Republic of China.

Funding

National Natural Science Foundation of China 82371123Shanghai Science and Technology Committee Foundation 21JC1401100Shanghai Science and Technology Committee Foundation 23Y31900500the National Key Clinical specialty construction project Z155080000004the New Technologies of Endoscopic Surgery in Skull Base Tumor: CAMS Innovation Fund for Medical Sciences (CIFMS) 2019-I2M-5-003the Young Program of National Natural Science Foundation of China 82201255
6 · The paper itself

Abstract

Allergic rhinitis (AR) is a prevalent chronic condition that significantly impacts patients' quality of life and strains healthcare systems. Current treatments, primarily involving therapeutic proteins such as antibodies and cytokines, have limitations, including injection requirements, short half-lives, and potential side effects. This study developed an indole-induced transgene system (ITS), utilizing the olfactory receptor Olfr205 to activate gene expression in response to indole. Incorporated in an adeno-associated virus vector, the ITS was tested in a mouse model of AR, with functionality assessed through

Indexed as

Genetic TherapyIndolesRhinitis, AllergicTransgenesAnimalsCytokinesDependovirusDisease Models, AnimalGenetic VectorsHumansMiceMice, Inbred BALB CReceptors, OdorantCytokinesindoleIndolesReceptors, OdorantAAV vectorantiinflammatory therapyOlfr205transgenic expression systemΔmIL-4

Identifiers

PMID40305665
PMCPMC12334887

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.