Evidence map›Paper›PMID 40305624›Full record

ArticleScience advances2025

Biomimetic elasticity compressed assembly controls rapid intracerebral drug release to reverse microglial dysfunction.

Guochen Han, Yi Jin, Kaiwen Bai, Qiaofei Du, Xiaochen Gu, Ling Tao, Jianping Zhou, Huaqing Zhang, Yang Ding

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Biological Applications of Functionalized Cerium Oxide Nanoparticles.International journal of medical sciences · 2026
    Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Guochen HanState Key Laboratory of Natural Medicines, Department of Pharmaceutics, China Pharmaceutical University, Nanjing 210009, China.ORCID 0009-0004-5659-1986
Yi JinState Key Laboratory of Natural Medicines, Department of Pharmaceutics, China Pharmaceutical University, Nanjing 210009, China.ORCID 0000-0003-4759-5323
Kaiwen BaiState Key Laboratory of Natural Medicines, Department of Pharmaceutics, China Pharmaceutical University, Nanjing 210009, China.ORCID 0009-0008-9311-2744
Qiaofei DuState Key Laboratory of Natural Medicines, Department of Pharmaceutics, China Pharmaceutical University, Nanjing 210009, China.
Xiaochen GuFaculty of Pharmacy, University of Manitoba, Winnipeg, MB R3E 0T5, Canada.
Ling TaoState Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014, China.ORCID 0000-0003-4043-7146
Jianping ZhouState Key Laboratory of Natural Medicines, Department of Pharmaceutics, China Pharmaceutical University, Nanjing 210009, China.ORCID 0009-0000-8787-5034
Huaqing ZhangState Key Laboratory of Natural Medicines, Department of Pharmaceutics, China Pharmaceutical University, Nanjing 210009, China.ORCID 0000-0002-4137-2703
Yang DingState Key Laboratory of Natural Medicines, Department of Pharmaceutics, China Pharmaceutical University, Nanjing 210009, China.ORCID 0000-0003-2894-7303

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The regulation of microglial dysfunction has become increasingly prominent in treatment of Alzheimer's disease (AD). Herein, we develop a scalable polymer-involved biomimetic assembly that responds to intracerebral reactive oxygen species (ROS) for elastic spreading and concentration-dependent drug therapy. Structurally, a polymer of thermally sensitive deformation is selected for hydrophobic loading of curcumin (Cur) and coordinative grafting onto ultrasmall ceria (CeO

Indexed as

Alzheimer DiseaseBiomimetic MaterialsBiomimeticsCurcuminDrug LiberationMicrogliaAmyloid beta-PeptidesAnimalsCeriumDisease Models, AnimalHumansMicePhagocytosisReactive Oxygen SpeciesAmyloid beta-Peptidesceric oxideCeriumCurcuminReactive Oxygen Species

Identifiers

PMID40305624
PMCPMC12042905

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.