Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
24 authors.
Mikhael D ManurungLeiden University Center for Infectious Diseases (LU-CID), Leiden University Medical Center, Leiden, Netherlands.ORCID 0000-0003-2728-1829
Graham A HeieisLeiden University Center for Infectious Diseases (LU-CID), Leiden University Medical Center, Leiden, Netherlands.ORCID 0000-0001-9864-7272
Marion KönigLeiden University Center for Infectious Diseases (LU-CID), Leiden University Medical Center, Leiden, Netherlands.ORCID 0000-0002-9892-218X
Shohreh AzimiLeiden University Center for Infectious Diseases (LU-CID), Leiden University Medical Center, Leiden, Netherlands.ORCID 0000-0002-3117-5722
Malick NdaoDepartment of Immunology, Faculty of Medicine, Pharmacy, and Odontology, Cheikh Anta Diop University of Dakar, Dakar, Senegal.
Tom VeldhuizenLeiden University Center for Infectious Diseases (LU-CID), Leiden University Medical Center, Leiden, Netherlands.
Dennis HovingLeiden University Center for Infectious Diseases (LU-CID), Leiden University Medical Center, Leiden, Netherlands.ORCID 0000-0002-9246-5774
Pytsje T HoekstraLeiden University Center for Infectious Diseases (LU-CID), Leiden University Medical Center, Leiden, Netherlands.ORCID 0000-0002-7285-9223
Yvonne C M KruizeLeiden University Center for Infectious Diseases (LU-CID), Leiden University Medical Center, Leiden, Netherlands.ORCID 0000-0002-1401-8071
Linda J WammesLeiden University Center for Infectious Diseases (LU-CID), Leiden University Medical Center, Leiden, Netherlands.ORCID 0000-0002-6660-9738
Roberta MenafraLeiden Genome Technology Center, Leiden University Medical Center, Leiden, Netherlands.ORCID 0000-0002-5266-0639
Marouba CisseLeiden University Center for Infectious Diseases (LU-CID), Leiden University Medical Center, Leiden, Netherlands.ORCID 0000-0001-5359-7451
Souleymane MboupInstitute of Health Research, Epidemiological Surveillance, and Training, Dakar, Senegal.ORCID 0000-0002-7968-3320
Alioune DieyeDepartment of Immunology, Faculty of Medicine, Pharmacy, and Odontology, Cheikh Anta Diop University of Dakar, Dakar, Senegal.
Susan KloetLeiden Genome Technology Center, Leiden University Medical Center, Leiden, Netherlands.ORCID 0000-0001-9189-0640
Dicky L TahaparyDepartment of Internal Medicine, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia.ORCID 0000-0002-4048-5159
Taniawati SupaliDepartment of Parasitology, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia.ORCID 0000-0002-1209-402X
Manfred WuhrerCenter for Proteomics and Metabolomics, Leiden University Medical Center, Leiden, Netherlands.ORCID 0000-0002-0814-4995
Cornelis H HokkeLeiden University Center for Infectious Diseases (LU-CID), Leiden University Medical Center, Leiden, Netherlands.ORCID 0000-0003-3545-7804
Bart EvertsLeiden University Center for Infectious Diseases (LU-CID), Leiden University Medical Center, Leiden, Netherlands.ORCID 0000-0002-3764-5131
Ahmed MahfouzDepartment of Human Genetics, Leiden University Medical Center, Leiden, Netherlands.ORCID 0000-0001-8601-2149
Simon P JochemsLeiden University Center for Infectious Diseases (LU-CID), Leiden University Medical Center, Leiden, Netherlands.ORCID 0000-0002-4835-1032
Maria YazdanbakhshLeiden University Center for Infectious Diseases (LU-CID), Leiden University Medical Center, Leiden, Netherlands.ORCID 0000-0002-7666-1441
Moustapha MbowDepartment of Immunology, Faculty of Medicine, Pharmacy, and Odontology, Cheikh Anta Diop University of Dakar, Dakar, Senegal.ORCID 0000-0002-5745-2628
Funding
No grant is acknowledged in the PubMed record.
6 · The paper itself
Abstract
Urbanization affects environmental exposures and lifestyle, shaping immune system variation and influencing disease susceptibility and vaccine responses. Here, we present systems analysis of immune profiles across the rural-urban gradient, comparing rural and urban Senegalese with urban Dutch individuals. By integrating single-cell phenotyping, metabolic profiling, and functional analysis, we reveal a trajectory of immune remodeling along the gradient. This includes enrichment of proinflammatory CD11c
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Systems analysis unravels a common rural-urban gradient in immunological profile, function, and metabolic dependencies. · full record | OpenQuestion