Evidence map›Paper›PMID 40305606›Full record

ArticleScience advances2025

Bacterial pathogens hijack host cell peroxisomes for replication vacuole expansion and integrity.

Mohammad J Hossain, Katerina A Romanov, Jeffrey Jian, Louis C Swaby, Saumya Bandyopadhyay, Ivan Guan, Sean M Thomas, Andrew J Olive, Tamara J O'Connor

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Multivariate Statistical Analysis ofInternational journal of molecular sciences · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Mohammad J HossainDepartment of Biological Chemistry, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0009-0006-2330-5263
Katerina A RomanovDepartment of Biological Chemistry, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0009-0003-8214-7320
Jeffrey JianDepartment of Biological Chemistry, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0000-0002-5169-1396
Louis C SwabyDepartment of Biological Chemistry, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0000-0003-3577-1094
Saumya BandyopadhyayDepartment of Biological Chemistry, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0000-0002-9430-1431
Ivan GuanDepartment of Biological Chemistry, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Sean M ThomasDepartment of Microbiology and Molecular Genetics, Michigan State University, East Lansing, MI, USA.
Andrew J OliveDepartment of Microbiology and Molecular Genetics, Michigan State University, East Lansing, MI, USA.ORCID 0000-0003-3441-3113
Tamara J O'ConnorDepartment of Biological Chemistry, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0000-0003-2535-5820

Funding

Deciphering the role of peroxisomes in bacterial pathogenesisR01AI163273 · NIAID · JOHNS HOPKINS UNIVERSITY · PI Tamara O'Connor · 2022 to 2026
$2.9M
Genetic Mechanisms of Tissue-Resident Macrophage Maintenance and Function (Supplement)R35GM146795 · NIGMS · MICHIGAN STATE UNIVERSITY · PI Andrew Olive · 2022 to 2026
$2.0M
Defining redundant strategies central to Legionella replication vacuole formationR01AI125402 · NIAID · JOHNS HOPKINS UNIVERSITY · PI O'CONNOR, TAMARA · 2016 to 2019
$1.6M
NIAID NIH HHS R01 AI125402NIAID NIH HHS R01 AI163273NIGMS NIH HHS R35 GM146795
6 · The paper itself

Abstract

Pathogens manipulate host cell organelles to establish infection. There is extensive evidence of pathogen modulation of the endoplasmic reticulum, Golgi apparatus, mitochondria, endosomes, lysosomes, and nucleus. However, one organelle that has been largely overlooked in connection with bacterial pathogenesis is peroxisomes. Here, we demonstrate that

Indexed as

Host-Pathogen InteractionsLegionella pneumophilaPeroxisomesVacuolesBacterial ProteinsHeLa CellsHumansBacterial Proteins

Identifiers

PMID40305606
PMCPMC12042894

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.