Evidence map›Paper›PMID 40305570›Full record

ArticleScience translational medicine2025

Inclusion of a retroviral protease enhances the immunogenicity of VLP-forming mRNA vaccines against HIV-1 or SARS-CoV-2 in mice.

Peng Zhang, Mamta Singh, Vada A Becker, Jacob Croft, Yaroslav Tsybovsky, Vinay Gopan, Yuna Seo, Qingbo Liu, Denise Rogers, Huiyi Miao and 14 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science translational medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Peng ZhangLaboratory of Immunoregulation and Infectious Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA.ORCID 0000-0002-2132-8991
Mamta SinghLaboratory of Immunoregulation and Infectious Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA.
Vada A BeckerDepartment of Medicinal Chemistry, University of Washington, Seattle, WA 98195, USA.ORCID 0000-0002-7658-7405
Jacob CroftDepartment of Medicinal Chemistry, University of Washington, Seattle, WA 98195, USA.ORCID 0000-0002-8964-3699
Yaroslav TsybovskyElectron Microscopy Laboratory, Cancer Research Technology Program, Leidos Biomedical Research, Frederick National Laboratory for Cancer Research, Frederick, MD 21701, USA.ORCID 0000-0002-2159-5248
Vinay GopanLaboratory of Immunoregulation and Infectious Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA.ORCID 0009-0000-4462-8009
Yuna SeoLaboratory of Immunoregulation and Infectious Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA.ORCID 0009-0005-3984-2840
Qingbo LiuLaboratory of Immunoregulation and Infectious Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA.ORCID 0000-0002-1347-6636
Denise RogersLaboratory of Immunoregulation and Infectious Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA.
Huiyi MiaoLaboratory of Immunoregulation and Infectious Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA.ORCID 0000-0001-9537-3288
Yin LinLaboratory of Immunoregulation and Infectious Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA.
Daniel RoganLaboratory of Immunoregulation and Infectious Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA.ORCID 0000-0002-9766-4166
Courtney ShieldsLaboratory of Immunoregulation and Infectious Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA.
Sayda M ElbashirModerna Inc., Cambridge, MA 02139, USA.ORCID 0000-0001-6250-9679
Samantha CalabreseModerna Inc., Cambridge, MA 02139, USA.
Isabella RenziModerna Inc., Cambridge, MA 02139, USA.ORCID 0000-0002-2677-7630
Vladimir PreznyakModerna Inc., Cambridge, MA 02139, USA.
Elizabeth NarayananModerna Inc., Cambridge, MA 02139, USA.ORCID 0000-0001-8836-181X
Guillaume Stewart-JonesModerna Inc., Cambridge, MA 02139, USA.ORCID 0009-0009-9645-9556
Sunny HimansuModerna Inc., Cambridge, MA 02139, USA.ORCID 0000-0002-7954-9674
Mark ConnorsLaboratory of Immunoregulation and Infectious Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA.
Kelly LeeDepartment of Medicinal Chemistry, University of Washington, Seattle, WA 98195, USA.ORCID 0000-0001-5577-9873
Andrea CarfiModerna Inc., Cambridge, MA 02139, USA.
Paolo LussoLaboratory of Immunoregulation and Infectious Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA.ORCID 0000-0002-2813-4081

Funding

Structure-Function Studies of the HIV-1 Envelope Glycoproteins and Development of VLP-forming vaccine strategies for HIV-1ZIAAI001197 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI LUSSO, PAOLO · 2014 to 2025
$16.8M
TRAINING IN MOLECULAR BIOPHYSICST32GM008268 · NIGMS · UNIVERSITY OF WASHINGTON · PI KOLLMAN, JUSTIN M, ZHENG, NING · 1988 to 2023
$8.6M
Gates Foundation INV-010646Intramural NIH HHS ZIA AI001197NIGMS NIH HHS T32 GM008268
6 · The paper itself

Abstract

Messenger RNA (mRNA) has emerged as a highly effective and versatile platform for vaccine delivery. We previously designed a virus-like particle (VLP)-forming

Indexed as

AIDS VaccinesCOVID-19COVID-19 VaccinesHIV-1HIV InfectionsImmunogenicity, VaccinePeptide HydrolasesRetroviridaeSARS-CoV-2Vaccines, Virus-Like ParticleAnimalsAntibodies, NeutralizingAntibodies, ViralFemaleHumansMiceAIDS VaccinesAntibodies, NeutralizingAntibodies, ViralCOVID-19 VaccinesmRNA VaccinesPeptide HydrolasesRNA, MessengerVaccines, Virus-Like Particle

Identifiers

PMID40305570
PMCPMC12151460

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.