SynthesisPloS one2025
School-based interventions to prevent anxiety and depression in children and adolescents in low- and middle-income countries: A systematic review.
Synthesis in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
3 citing papers in PubMed.
- Improving child mental health and learning outcomes and reducing stigma and discrimination in conflict setting: findings from a cluster randomized controlled trial of a classroom-based psychosocial intervention in rural primary schools in Afghanistan.Journal of child psychology and psychiatry, and allied disciplines · 2026Trial
- Exploring the role of resilience in selective prevention intervention for adolescents at risk of depression and anxiety in Nepal: findings from a pilot cluster randomized controlled trial.Child and adolescent psychiatry and mental health · 2025Article
- Childhood Obesity and Overweight Are Associated with Higher Risk of Depression and Anxiety: A Cross-Sectional Study in Children Aged 6-9 Years.Life (Basel, Switzerland) · 2025Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAnxiety and depression are on the rise among children and adolescents globally. Low- and middle-income countries (LMICs) face heightened vulnerability due to limited resources, restricted access to mental health services, socioeconomic disparities and widespread mental health stigma. Schools offer a unique and potentially impactful setting for preventive interventions targeting anxiety and depression in young individuals.
aimWe aimed to identify empirical research to explore the effectiveness of school-based interventions designed to prevent anxiety and depression among children and adolescents in LMICs.
methodOvid MEDLINE, Embase, PsycINFO and CENTRAL were systematically searched for articles published between 2018 and July 2023. Randomised controlled trials that evaluated school-based interventions for children and adolescents aged 4-18 years in LMICs were included. Only studies in English language were included. The primary outcomes were anxiety and/or depressive symptoms. Risk-of-bias assessments were performed.
resultsOut of 3863 articles identified, six studies comprising 1587 students met the inclusion criteria. Among the four studies that examined interventions for the prevention of both anxiety and depression, as well as anxiety alone, only one study showed a reduction in anxiety symptoms. In the case of depression, three out of four studies reported improvements in depressive symptoms. The finding suggests a potential effectiveness of preventive interventions against depression, but not anxiety. However, this finding should be interpreted with caution given the limited number of studies identified. All studies were either classified as high risk of bias or having some concerns.
conclusionThere is some evidence of the effectiveness of school-based interventions in preventing anxiety and depression among young people in LMICs. Further research is necessary to gain a more comprehensive understanding of this critical issue. Moving forward, it is crucial to enhance and broaden existing school-based prevention programs in these nations, exploring different intervention strategies tailored to their specific contextual factors.
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