Evidence map›Paper›PMID 40305381›Full record

ArticleEmerging infectious diseases2025

Administration of L-Type Bovine Spongiform Encephalopathy to Macaques to Evaluate Zoonotic Potential.

Morikazu Imamura, Ken'ichi Hagiwara, Minoru Tobiume, Minako Ohno, Hiromi Iguchi, Hanae Takatsuki, Tsuyoshi Mori, Ryuichiro Atarashi, Hiroaki Shibata, Fumiko Ono

Abstract read
In one paragraph

Article in Emerging infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Morikazu Imamura
Ken'ichi Hagiwara
Minoru Tobiume
Minako Ohno
Hiromi Iguchi
Hanae Takatsuki
Tsuyoshi Mori
Ryuichiro Atarashi
Hiroaki Shibata
Fumiko Ono

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We administered L-type bovine spongiform encephalopathy prions to macaques to determine their potential for transmission to humans. After 75 months, no clinical symptoms appeared, and prions were undetectable in any tissue by Western blot or immunohistochemistry. Protein misfolding cyclic amplification, however, revealed prions in the nerve and lymphoid tissues.

Indexed as

Encephalopathy, Bovine SpongiformPrionsPrPSc ProteinsZoonosesAnimalsBrainCattleHumansMacacaPrionsPrPSc Proteinsbovine spongiform encephalopathycynomolgus macaquesJapanL-Type bovine spongiform encephalopathyMacaca fascicularisoral transmissionprionszoonoses

Identifiers

PMID40305381
PMCPMC12044238

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.