Trial reportDeutsches Arzteblatt international2025
A Smartphone-Guided Digital Health Application for Hypertension: The Randomized Controlled HELP Trial.
Trial report in Deutsches Arzteblatt international, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Exercise Training Across the Hypertensive Heart Disease Continuum: Clinical Evidence and Implications for Prescription.Journal of cardiovascular development and disease · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHypertension is a significant risk factor for cardiovascular disease development. Current guidelines recommend a combination of medication and lifestyle modifications, particularly with regard to diet, exercise, blood pressure monitoring, and therapy adherence. To support this, the digital health application "Vantis Bluthochdruck" (Vantis app) was developed.
methodsA prospective trial in 98 patients with uncontrolled hypertension at seven German centers tested whether the Vantis app lowers systolic blood pressure. Patients were randomized 1:1 to the app or standard care, with investigators blinded to group allocation at baseline. The primary endpoint was systolic blood pressure after 13 weeks, and the secondary endpoints were therapy adherence, diastolic blood pressure, resting heart rate, body mass index, and unplanned medical visits. The study is registered under DRKS00031923.
resultsThe intervention group showed a significantly greater reduction in the primary endpoint, systolic blood pressure, than the control group (difference 5.5 mmHg, 95% confidence interval [1.3; 9.8]; p = 0.011). Systolic blood pressure fell from 151.4 mmHg [149.1; 153.8] to 144.3 mmHg [141.2; 147.3] in the control group and from 152.5 mmHg [149.8; 155.2] to 140.1 mmHg [136.7; 143.5] in the intervention group. Patients in the intervention group exhibited higher therapy adherence with no differences in other secondary endpoints. No app-related adverse events were reported.
conclusionThe study indicates that the tested digital health application lowers systolic blood pressure in hypertensive patients and increases guideline adherence.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.