Evidence map›Paper›PMID 40305349›Full record

ArticleBiomolecules2025

Regeneration of Two-Walled Infrabony Periodontal Defects in Swine After Buccal Fat Pad-Derived Dedifferentiated Fat Cell Autologous Transplantation.

Daisuke Akita, Naoki Tsukimura, Tomohiko Kazama, Rie Takahashi, Yoshiki Taniguchi, Jin Inoue, Ayana Suzuki, Nodoka Tanabe, Keisuke Seki, Yoshinori Arai and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Daisuke AkitaDepartment of Partial Denture Prosthodontics, Nihon University School of Dentistry, Tokyo 101-8310, Japan.
Naoki TsukimuraDivision of General Dentistry, The Nippon Dental University School of Life Dentistry, Tokyo 102-8158, Japan.
Tomohiko KazamaDivision of Cell Regeneration and Transplantation, Department of Functional Morphology, Nihon University School of Medicine, Tokyo 173-8610, Japan.
Rie TakahashiSection of Laboratory Animals, Nihon University School of Medicine, Tokyo 173-8601, Japan.
Yoshiki TaniguchiSection of Laboratory Animals, Nihon University School of Medicine, Tokyo 173-8601, Japan.
Jin InoueDivision of Applied Oral Sciences, Nihon University Graduate School of Dentistry, Tokyo 101-8310, Japan.
Ayana SuzukiDivision of Applied Oral Sciences, Nihon University Graduate School of Dentistry, Tokyo 101-8310, Japan.
Nodoka TanabeDivision of Applied Oral Sciences, Nihon University Graduate School of Dentistry, Tokyo 101-8310, Japan.
Keisuke SekiDepartment of Comprehensive Dentistry and Clinical Education, Nihon University School of Dentistry, Tokyo 101-8310, Japan.ORCID 0000-0002-6130-1259
Yoshinori AraiDepartment of Oral and Maxillofacial Radiology, Nihon University School of Dentistry, Tokyo 101-8310, Japan.
Masatake AsanoDepartment of Pathology, Nihon University School of Dentistry, Tokyo 101-8310, Japan.ORCID 0000-0003-0028-8262
Shuichi SatoDepartment of Periodontology, Nihon University School of Dentistry, Tokyo 101-8310, Japan.
Yoshiyuki HagiwaraDepartment of Partial Denture Prosthodontics, Nihon University School of Dentistry, Tokyo 101-8310, Japan.ORCID 0000-0001-6647-7969
Koichiro KanoLaboratory of Cell and Tissue Biology, College of Bioresource Science, Nihon University, Fujisawa 252-0880, Japan.ORCID 0000-0001-6190-0780
Masaki HondaDepartment of Oral Anatomy, Aichi Gakuin University School of Dentistry, Nagoya 464-8650, Japan.ORCID 0000-0002-2539-7986
Taro MatsumotoDivision of Cell Regeneration and Transplantation, Department of Functional Morphology, Nihon University School of Medicine, Tokyo 173-8610, Japan.ORCID 0000-0002-2965-2673

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mature adipocyte-derived dedifferentiated fat (DFAT) cells show proliferative capabilities and multipotency. Given that the buccal fat pad (BFP) serves as a readily available resource for DFAT cell isolation, BFP-derived DFAT (BFP-DFAT) cells are a promising candidate in orofacial tissue engineering. In this research, we assessed the regenerative capacity of the periodontium through autologous BFP-DFAT cell transplantation in adult swine (micro-minipigs; MMPs). The BFP-DFAT cells were transplanted into inflammation-inducing two-walled infrabony periodontal defects located on the mesial of the second mandibular premolar (

Indexed as

AdipocytesAdipose TissueRegenerationAnimalsCell DedifferentiationSwineSwine, MiniatureTissue EngineeringTransplantation, Autologousdedifferentiated fat cells (DFAT cells)periodontal tissue regenerationtransplantationtwo-walled infrabony periodontal defect

Identifiers

PMID40305349
PMCPMC12024700

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.