Evidence map›Paper›PMID 40305315›Full record

ArticleBiomolecules2025

Hydroxyzine Effects on Post-Lanosterol Biosynthesis in Smith-Lemli-Opitz Syndrome (SLOS) Models.

Zeljka Korade, Allison C Anderson, Marta Balog, Keri A Tallman, Ned A Porter, Karoly Mirnics

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Zeljka KoradeDepartment of Pediatrics, Biochemistry and Molecular Biology, College of Medicine, University of Nebraska Medical Center, Child Health Research Institute, Omaha, NE 68198, USA.ORCID 0000-0002-8690-4507
Allison C AndersonMunroe-Meyer Institute for Genetics and Rehabilitation, University of Nebraska Medical Center, Child Health Research Institute, Omaha, NE 68198, USA.ORCID 0000-0002-3511-939X
Marta BalogMunroe-Meyer Institute for Genetics and Rehabilitation, University of Nebraska Medical Center, Child Health Research Institute, Omaha, NE 68198, USA.ORCID 0000-0002-7842-4781
Keri A TallmanDepartment of Chemistry, Vanderbilt Institute of Chemical Biology and Vanderbilt Kennedy Center for Research on Human Development, Vanderbilt University, Nashville, TN 37240, USA.ORCID 0000-0001-7331-2601
Ned A PorterDepartment of Chemistry, Vanderbilt Institute of Chemical Biology and Vanderbilt Kennedy Center for Research on Human Development, Vanderbilt University, Nashville, TN 37240, USA.
Karoly MirnicsMunroe-Meyer Institute for Genetics and Rehabilitation, University of Nebraska Medical Center, Child Health Research Institute, Omaha, NE 68198, USA.ORCID 0000-0002-5521-0254

Funding

Reversing disrupted developmental sterol biosynthesis by prescription medicationsR56HD111119 · NICHD · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI KORADE, ZELJKA, MIRNICS, KAROLY · 2024 to 2024
$230k
NICHD NIH HHS R56 HD111119NIH/NICHD R56HD111119 KM ZK
6 · The paper itself

Abstract

Smith-Lemli-Opitz syndrome (SLOS) is a developmental disability arising from bi-allelic pathogenic variants in the 7-dehydrocholestrol reductase (DHCR7) enzyme and the accumulation of 7-dehydrocholesterol (7-DHC). 7-DHC spontaneously oxidizes and gives rise to cytotoxic oxysterols. Our recent high-throughput screening on

Indexed as

LanosterolSmith-Lemli-Opitz SyndromeAnimalsDehydrocholesterolsDisease Models, AnimalFibroblastsHumansMiceMice, TransgenicNeuronsOxidoreductases Acting on CH-CH Group Donors7-dehydrocholesterol7-dehydrocholesterol reductaseDehydrocholesterolsLanosterolOxidoreductases Acting on CH-CH Group Donors7-DHCdesmosterolDHCR7LC-MS/MSsterol biosynthesis

Identifiers

PMID40305315
PMCPMC12024545

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.