Evidence map›Paper›PMID 40305308›Full record

ArticleBiomolecules2025

Identification of TSSK1 and TSSK2 as Novel Targets for Male Contraception.

Saman Nayyab, Marıá Gracia Gervasi, Darya A Tourzani, Yeva Shamailova, Hiroki Akizawa, Mahboubeh Taghavi, Wei Cui, Rafael Fissore, Ana Maria Salicioni, Gunda I Georg and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. [Male contraception-scientific foundations and contemporary progress].Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz · 2026
    Review
  2. Review
  3. Frontiers in immunology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Saman NayyabDepartment of Veterinary and Animal Sciences, University of Massachusetts-Amherst, Amherst, MA 01003, USA.
Marıá Gracia GervasiDepartment of Animal Science, University of Connecticut, Storrs, CT 06269, USA.
Darya A TourzaniDepartment of Veterinary and Animal Sciences, University of Massachusetts-Amherst, Amherst, MA 01003, USA.
Yeva ShamailovaDepartment of Animal Science, Rutgers University, New Brunswick, NJ 08901, USA.
Hiroki AkizawaDepartment of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0003-1091-5629
Mahboubeh TaghaviDepartment of Veterinary and Animal Sciences, University of Massachusetts-Amherst, Amherst, MA 01003, USA.
Wei CuiAnimal Models Core Facility, Institute for Applied Life Sciences (IALS), University of Massachusetts-Amherst, Amherst, MA 01003, USA.ORCID 0000-0001-7281-3471
Rafael FissoreDepartment of Veterinary and Animal Sciences, University of Massachusetts-Amherst, Amherst, MA 01003, USA.
Ana Maria SalicioniDepartment of Veterinary and Animal Sciences, University of Massachusetts-Amherst, Amherst, MA 01003, USA.
Gunda I GeorgDepartment of Medicinal Chemistry, Institute for Therapeutics Discovery and Development, University of Minnesota, Minneapolis, MN 55455, USA.ORCID 0000-0002-8900-9460
Elizabeth SnyderDepartment of Animal Science, Rutgers University, New Brunswick, NJ 08901, USA.ORCID 0000-0002-3786-3753
Pablo E ViscontiDepartment of Veterinary and Animal Sciences, University of Massachusetts-Amherst, Amherst, MA 01003, USA.ORCID 0000-0001-9320-7518

Funding

Novel mechanisms regulating translation elongation during male germ cell differentiationR01HD107066 · NICHD · RUTGERS, THE STATE UNIV OF N.J. · PI Elizabeth M, Snyder · 2022 to 2026
$1.7M
NICHD NIH HHS R01 HD107066NIH HHS 1R01HD038082-21A1
6 · The paper itself

Abstract

The testis-specific serine kinases (TSSKs) are post-meiotically expressed in testicular germ cells. Their testis-specific expression, together with their putative role in phosphorylation pathways, suggests that TSSKs have relevant roles in spermiogenesis, sperm function, or both. Independent

Indexed as

ContraceptionProtein Serine-Threonine KinasesAnimalsCRISPR-Cas SystemsFemaleInfertility, MaleMaleMiceMice, KnockoutSpermatogenesisSpermatozoaSperm MotilityTestisProtein Serine-Threonine KinasesKOmale contraceptionspermiogenesissterilitytestis-specific kinasesTSSK1TSSK2

Identifiers

PMID40305308
PMCPMC12024862

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.