Antitumor Assessment of Liposomal Beta-Carotene with Tamoxifen Against Breast Carcinoma Cell Line: An In Vitro Study.

Marim H Elsayed, Medhat W Shafaa, Mohga S Abdalla, Manal F El-Khadragy, Ahmed E Abdel Moneim, Shimaa S Ramadan

Abstract read

In one paragraph

Article in Biomolecules, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Liposomal formulation ofRSC advances · 2025
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Marim H ElsayedMolecular Biotechnology Sector, Chemistry Department, Faculty of Science, Helwan University, Cairo 11795, Egypt.

Medhat W ShafaaMedical Biophysics Division, Physics Department, Faculty of Science, Helwan University, Cairo 11795, Egypt.

Mohga S AbdallaBiochemistry Sector, Chemistry Department, Faculty of Science, Helwan University, Cairo 11795, Egypt.

Manal F El-KhadragyDepartment of Biology, College of Science, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh 11671, Saudi Arabia.

Ahmed E Abdel MoneimZoology and Entomology Department, Faculty of Science, Helwan University, Cairo 11795, Egypt.

Shimaa S RamadanBiochemistry Sector, Chemistry Department, Faculty of Science, Helwan University, Cairo 11795, Egypt.ORCID 0000-0002-6342-8608

Funding

Princess Nourah bint Abdulrahman University Researchers Supporting Project PNURSP2025R23

6 · The paper itself

Abstract

The present study was designed to characterize the interactions between lecithin liposomes, a model membrane, and either β-carotene or tamoxifen. In addition, the cytotoxicity of liposomal beta-carotene with tamoxifen was screened in vitro in human breast cancer cell lines MCF-7 and MDA-MB-231 in addition to the normal WI38 cell line. All liposomes were nearly spherical and evenly distributed and had fewer aggregates for encapsulated and empty vesicles. Measurements using dynamic light scattering verified that each sample was monodisperse. When tamoxifen is incorporated into liposomal membranes, the zeta potential values tend to decrease. In the test for cytotoxicity using MCF-7 treated cells, the liposomal β-carotene IC

Indexed as

Antineoplastic Agentsbeta CaroteneBreast NeoplasmsLiposomesTamoxifenApoptosisCell Line, TumorCell SurvivalFemaleHumansMCF-7 CellsAntineoplastic Agentsbeta CaroteneLiposomesTamoxifenapoptosisbeta-caroteneDSCFTIRliposomestamoxifen

Identifiers

PMID40305216

DOI10.3390/biom15040486

PMCPMC12024615

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.