Evidence map›Paper›PMID 40305189›Full record

ArticleBiomolecules2025

Scanning Tunneling Microscope Measurement of Proteasome Conductance.

Sepideh Afsari, Eathen Ryan, Brian Ashcroft, Xu Wang, Stuart Lindsay

Abstract read
In one paragraph

Article in Biomolecules, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Conducting Atomic Force Microscopy of Protein Wires.Small (Weinheim an der Bergstrasse, Germany) · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Sepideh AfsariBiodesign Institute, Arizona State University, Tempe, AZ 85287, USA.ORCID 0000-0002-9274-0780
Eathen RyanBiodesign Institute, Arizona State University, Tempe, AZ 85287, USA.
Brian AshcroftBiodesign Institute, Arizona State University, Tempe, AZ 85287, USA.
Xu WangSchool of Molecular Sciences, Arizona State University, Tempe, AZ 85287, USA.ORCID 0000-0002-7369-677X
Stuart LindsayBiodesign Institute, Arizona State University, Tempe, AZ 85287, USA.ORCID 0000-0002-9364-6542

Funding

Direct Electrical Measurement of Proteasome Activity for Single-Molecule Protein SequencingR21HG012538 · NHGRI · ARIZONA STATE UNIVERSITY-TEMPE CAMPUS · PI LINDSAY, STUART · 2022 to 2022
$432k
Sequencing Glycosaminoglycans using Single Molecule Enzyme Conductance FluctuationsR21GM148682 · NIGMS · ARIZONA STATE UNIVERSITY-TEMPE CAMPUS · PI WANG, XU · 2023 to 2024
$414k
NHGRI NIH HHS R21 HG012538NIGMS NIH HHS R21 GM148682
6 · The paper itself

Abstract

The proteasome is an enzyme that sequentially degrades peptides into small fragments, so the ability to make electrical measurements of its conformational fluctuations could lead to an electronic readout of the sequence of single peptide molecules. Here, we report scanning tunneling microscope (STM) measurements of the conductance of the

Indexed as

Microscopy, Scanning TunnelingProteasome Endopeptidase ComplexElectric ConductivityProteasome Endopeptidase Complexelectronic sequencingproteasomeprotein conductanceprotein electrical contactsprotein electronicsscanning tunneling microscopy

Identifiers

PMID40305189
PMCPMC12024802

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.