Evidence map›Paper›PMID 40305171›Full record

ArticleBiomolecules2025

Ruthenium(II)-Arene Complexes with a 2,2'-Bipyridine Ligand as Anti-Aβ Agents.

Ryan M Hacker, Jacob J Smith, David C Platt, William W Brennessel, Marjorie A Jones, Michael I Webb

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ryan M HackerDepartment of Chemistry and Biochemistry, SUNY Geneseo, Geneseo, NY 14454, USA.
Jacob J SmithDepartment of Chemistry and Biochemistry, SUNY Geneseo, Geneseo, NY 14454, USA.
David C PlattDepartment of Chemistry, Illinois State University, Normal, IL 69701, USA.
William W BrennesselDepartment of Chemistry, University of Rochester, Rochester, NY 14627, USA.ORCID 0000-0001-5461-1825
Marjorie A JonesDepartment of Chemistry, Illinois State University, Normal, IL 69701, USA.ORCID 0000-0002-6306-0700
Michael I WebbDepartment of Chemistry and Biochemistry, SUNY Geneseo, Geneseo, NY 14454, USA.ORCID 0000-0002-4708-2694

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Agents that target the amyloid-β (Aβ) peptide associated with Alzheimer's disease have seen renewed interest following the clinical success of antibody therapeutics. Small molecules, specifically metal-based complexes, are excellent candidates for advancement, given their relative ease of preparation and modular scaffold. Herein, several ruthenium-arene complexes containing 2,2-bipyridine (bpy) ligands were prepared and evaluated for their respective ability to modulate the aggregation of Aβ. This was carried out using the three sequential methods of thioflavin T (ThT) fluorescence, dynamic ligand scattering (DLS), and transmission electron microscopy (TEM). Overall, it was observed that

Indexed as

2,2'-DipyridylAmyloid beta-PeptidesCoordination ComplexesRutheniumAlzheimer DiseaseHumansLigandsProtein Aggregates2,2'-DipyridylAmyloid beta-PeptidesCoordination ComplexesLigandsProtein AggregatesRutheniumAlzheimer’s diseaseamyloid-βhuman serum albuminruthenium therapeutics

Identifiers

PMID40305171
PMCPMC12024814

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.