Evidence map›Paper›PMID 40305119›Full record

ArticleMolecular biology of the cell2025

The PCM scaffold enables RNA localization to centrosomes.

Junnan Fang, Weiyi Tian, Melissa A Quintanilla, Jordan R Beach, Dorothy A Lerit

Abstract read
In one paragraph

Article in Molecular biology of the cell, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Centriolar satellites regulateMolecular biology of the cell · 2026
    Article
  2. Centriolar satellites regulatebioRxiv : the preprint server for biology · 2026
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Junnan FangDepartment of Cell Biology, Emory University School of Medicine, Atlanta, GA 30322.
Weiyi TianEmory College of Arts and Sciences, Emory University, Atlanta, GA 30322.
Melissa A QuintanillaDepartment of Cell and Molecular Physiology, Stritch School of Medicine, Loyola University Chicago, Maywood, IL 60153.
Jordan R BeachDepartment of Cell and Molecular Physiology, Stritch School of Medicine, Loyola University Chicago, Maywood, IL 60153.ORCID 0000-0003-0633-4928
Dorothy A LeritDepartment of Cell Biology, Emory University School of Medicine, Atlanta, GA 30322.ORCID 0000-0002-3362-8078

Funding

MECHANISMS OF CONTRACTILE NETWORK ASSEMBLYR35GM138183 · NIGMS · LOYOLA UNIVERSITY CHICAGO · PI Jordan Beach · 2020 to 2026
$2.8M
Post-transcriptional mechanisms of centrosome regulationR01GM138544 · NIGMS · EMORY UNIVERSITY · PI LERIT, DOROTHY A · 2020 to 2024
$1.8M
Isoform expression and post-transcriptional regulation of centrosomal plp mRNAR00GM143517 · NIGMS · OHIO STATE UNIVERSITY · PI JUNNAN FANG · 2025 to 2026
$498k
Isoform expression and post-transcriptional regulation of centrosomal plp mRNAK99GM143517 · NIGMS · EMORY UNIVERSITY · PI FANG, JUNNAN · 2022 to 2023
$225k
NIGMS NIH HHS K99 GM143517NIGMS NIH HHS R00 GM143517NIGMS NIH HHS R01 GM138544NIGMS NIH HHS R35 GM138183
6 · The paper itself

Abstract

As microtubule-organizing centers, centrosomes direct assembly of the bipolar mitotic spindle required for chromosome segregation and genome stability. Centrosome activity requires the dynamic assembly of pericentriolar material (PCM), the composition and organization of which changes throughout the cell cycle. Recent studies highlight the conserved localization of several mRNAs encoded from centrosome-associated genes enriched at centrosomes, including

Indexed as

CentrosomeAntigensHeLa CellsHumansMicrotubule-Organizing CenterRNA, MessengerRNA TransportSpindle ApparatusAntigenspericentrinRNA, Messenger

Identifiers

PMID40305119
PMCPMC12206496

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.